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These hormonal levels are highly specific to this disease and serve as key diagnostic indicators. Herein, we present a detailed clinical course of a 69\u2010year\u2010old male with a history of gastric cancer and lymph node metastases who developed anti\u2010PIT\u20101 hypophysitis after the initiation of immune checkpoint inhibitor (ICI) therapy, specifically nivolumab, oxaliplatin, and capecitabine. The patient was referred to our department owing to decreased TSH, free triiodothyronine (T3), and free thyroxine (T4) levels after two doses of nivolumab. Initially suspected as central hypothyroidism due to ICI\u2010related hypophysitis, further assessment confirmed the diagnosis of anti\u2010PIT\u20101 hypophysitis. Notably, GH, PRL, and TSH levels markedly declined, leading to complete deficiencies 2\u2009months after the first nivolumab dose\u2014a pattern consistent with that of previous cases of anti\u2010PIT\u20101 hypophysitis. Therefore, this report not only presents an atypical subset of ICI\u2010related hypophysitis but also delineates the process of hormone impairment leading to complete deficiencies in anti\u2010PIT\u20101 hypophysitis. This case highlights the importance of vigilant monitoring for endocrine issues in patients undergoing ICI therapy, given the escalating incidence of immune\u2010related adverse events associated with the extensive use of ICI therapy for various cancers.<\/jats:p>","DOI":"10.1111\/jne.13395","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:08:52Z","timestamp":1713398932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The early\u2010stage clinical course of anti\u2010pituitary\u2010specific transcription factor\u20101 hypophysitis diagnosed post\u2010immune checkpoint inhibitor treatment: A case with review of literature"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-232X","authenticated-orcid":false,"given":"Shin","family":"Urai","sequence":"first","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of 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