{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:48Z","timestamp":1772160708564,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Somatostatin receptor positron emission tomography with computerised tomography imaging (SRI) has a high sensitivity for the detection of small intestinal neuroendocrine tumors (siNET), which makes it ideal for follow\u2010up. The aim of the present study was to investigate whether follow\u2010up with SRI in patients with siNET led to any change in the treatment of the patient and if patient and\/or tumour factors were associated with such change. Adults with siNET who had undergone at least two SRI scans between 2013 and 2021 were identified. Data on age, sex, comorbidities, tumour stage, grade, and most recent levels of serum Chromogranin A (CgA) and 24\u2010h urine 5\u2010hydroxyindoleacetic acid (5\u2010HIAA) before each SRI scan were obtained. The major change was defined as new treatment previously not received or discontinuation of ongoing treatment. Univariate and multivariate mixed models logistic regression on variables with a presumed biological relationship with major change and with backwards stepwise exclusion of variables with\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.1 was performed. A total of 164 patients with siNET diagnosis had undergone 570 SRI scans. The median follow\u2010up was 3.1\u2009years. Only 82 of 570, 14%, of SRI scans led to a major change in treatment. Female sex, age below 75\u2009years, elevated or missing CgA, elevated or missing urine 5\u2010HIAA, progress on last SRI scan and distant extrahepatic disease were all independently associated with increased odds ratios for major change after follow\u2010up with SRI. A small proportion of SRI scans (14%) led to a major change in treatment. Six independent risk factors with increased odds of major change, all available before each SRI scan, were identified. While validation of these risk factors is needed in a separate cohort, these findings could help clinicians individualise follow\u2010up for siNET patients in the future.\n                  <\/jats:p>","DOI":"10.1111\/jne.13396","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T01:54:51Z","timestamp":1714355691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimal follow\u2010up with somatostatin receptor\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    imaging in patients with small intestinal neuroendocrine tumours"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-3727","authenticated-orcid":false,"given":"H\u00e5kan","family":"Ohlsson","sequence":"first","affiliation":[{"name":"Department of Surgery Ystad Hospital  Ystad Sweden"},{"name":"Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Spaak","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Surgery Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anni","family":"G\u00e5lne","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sundl\u00f6v","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Oncology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Almquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Endocrine\u2010Sarcoma Unit, Department of Surgery Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/THEONCOLOGIST.2011\u20100002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00268\u2010011\u20101296\u2010Z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201021\u20100354"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAONCOL.2018.0024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443170"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.304"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.257808"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0B013E3181FD37E8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001625"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/DIAGNOSTICS11020334"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010017\u20103728\u2010y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.040378"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ANNONC\/MDQ022"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.733953"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758834016675803"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0154679"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2008.02.052"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000162876"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509091"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00980"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SURONC.2020.09.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13139\u2010020\u201000677\u20100"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNONC.2020.04.481"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CRITREVONC.2017.03.017"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2018.00740\/BIBTEX"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201019\u20100030"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/THEONCOLOGIST.2017\u20100623"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446025"}],"container-title":["Journal 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