{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T12:37:17Z","timestamp":1785674237704,"version":"3.56.0"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["GRANT13694731"],"award-info":[{"award-number":["GRANT13694731"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The impact of heat stress (HS) on production is intricately linked with feed intake. We investigated the effects of HS on intestines and diencephalic genes in Pekin ducks. One hundred and sixty adult ducks were allocated to two treatment rooms. The control room was maintained at 22\u00b0C and the HS room at 35\u00b0C for the first 10\u2009h of the day then reduced to 29.5\u00b0C. After 3\u2009weeks, 10 hens and 5 drakes were euthanized from each room and jejunum and ileum collected for histology. Brains were collected for gene expression analysis using qRT\u2010PCR. Intestinal morphology data were analyzed with two\u2010way ANOVA and diencephalic gene data were analyzed with Kruskal\u2013Wallis test. There was an increase in villi width in the ileum (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0136) and jejunum (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0019) of HS hens compared to controls. HS drakes showed a higher crypt depth (CD) in the jejunum (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0198) compared to controls. There was an increase in crypt goblet cells (GC) count in the ileum (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0169) of HS drakes compared to HS hens. There was higher villi GC count (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.07) in the jejunum of HS drakes compared to controls. There was an increase in the crypt GC density (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0054) in the ileum, not jejunum, of HS drakes compared to HS hens. Further, there were no differences in the proopiomelanocortin gene expression in either sex but there was an increase in the expression of neuropeptide Y (NPY) gene in HS hens (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.031) only and a decrease in the corticotropin releasing hormone gene in the HS drakes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.037) compared to controls. These data show that there are sex differences in the effect of HS on gut morphology while the upregulation in NPY gene may suggest a role in mediating response to chronic HS.\n                  <\/jats:p>","DOI":"10.1111\/jne.13424","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T21:29:10Z","timestamp":1720042150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex differences in intestinal morphology and increase in diencephalic neuropeptide Y gene expression in female but not male Pekin ducks exposed to chronic heat stress"],"prefix":"10.1111","volume":"37","author":[{"given":"E. 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