{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:57:59Z","timestamp":1788875879911,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Growth hormone (GH) has a short half\u2010life and declines abruptly following somatotropinoma surgery, enabling its prompt measurement as an indicator of surgical success. This study assesses the predictive value of early postoperative GH levels for 3\u2010month and &gt;1\u2010year remission of acromegaly. We conducted a retrospective search in our database of patients who had undergone transsphenoidal surgery of GH\u2010secreting pituitary adenoma from January 2011 to June 2022. Only the patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The 3\u2010month and &gt;1\u2010year remission of acromegaly was defined as achieving the GH nadir of &lt;0.4\u2009\u03bcg\/L during an oral glucose tolerance test and maintaining normal insulin\u2010like growth factor 1 levels at the initial follow\u2010up visit 3 months after surgery and throughout at least the first year postoperation. We included 63 patients in the analysis, with a median follow\u2010up of 51.8 (13\u2013155) months. The 3\u2010month remission was achieved in 42 (66.7%) patients, and &gt;1\u2010year remission without additional therapy in 38 (60.3%) patients. Those who achieved &gt;1\u2010year remission had significantly lower fifth\u2010day postoperative GH levels (0.59 [0.09\u20138.92] vs. 2.63 [0.25\u201324.64] \u03bcg\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Receiver\u2010operating characteristic analysis revealed a significant value of fifth\u2010day postoperative GH levels regarding the prediction of 3\u2010month (area under the curve [AUC], 0.834;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001) and &gt;1\u2010year (AUC, 0.783;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001) acromegaly remission. The GH threshold of \u22641.57\u2009\u03bcg\/L yielded a sensitivity of 90.5% and a specificity of 71.4% at 3\u2009months and 89.5% sensitivity and 60% specificity at the &gt;1\u2010year remission, respectively. Notably, all patients with fifth\u2010day postoperative GH levels \u22640.23\u2009\u03bcg\/L exhibited remission of acromegaly throughout the follow\u2010up period. Early postoperative GH measurement could be a reliable predictor of both 3\u2010month and &gt;1\u2010year remission of acromegaly.\n                  <\/jats:p>","DOI":"10.1111\/jne.13434","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T04:25:21Z","timestamp":1721967921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early postoperative growth hormone measurement as a predictive marker for acromegaly remission"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-2250","authenticated-orcid":false,"given":"Ivana","family":"Kraljevic","sequence":"first","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"},{"name":"School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirsala","family":"Solak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kovac","sequence":"additional","affiliation":[{"name":"County Emergency Medicine Institute  Dubrovnik Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja Skoric","family":"Polovina","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Zibar","family":"Tomsic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Balasko","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-3501","authenticated-orcid":false,"given":"Tina","family":"Dusek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"},{"name":"School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-5598","authenticated-orcid":false,"given":"Darko","family":"Kastelan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb  Zagreb Croatia"},{"name":"School of Medicine University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201016\u20100106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102\u2010017\u20100797\u20107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010016\u20102903\u20104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab069"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20102700"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009\u20102670"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.3.FOCUS2080"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17\u20100261"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010021\u201001553\u20100"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010014\u20102098\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010018\u20101590\u20108"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028\u20103886.177622"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517476"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102\u2010020\u201001063\u2010x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102\u2010023\u201001360\u20101"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS141083"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510152567103"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.4.0719"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.12.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.8.JNS13790"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31823f5c16"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102\u2010020\u201001094\u20104"}],"container-title":["Journal 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