{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:50:17Z","timestamp":1789145417352,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypothalamic obesity (HO) is defined as abnormal weight gain resulting in severe persistent obesity due to physical, tumor\u2010 and\/or treatment\u2010related damage to the hypothalamus. HO epidemiology is poorly understood. We developed a database algorithm supporting the standardized identification of tumor\/treatment\u2010related HO (TTR\u2010HO) patients. The algorithm is used to estimate incidence rates of TTR\u2010HO patients in the German healthcare context from a representative claims database (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095.42 million) covering 2010\u20132020. Patients were identified based on surgery\/radiotherapy procedures and HO\u2010associated tumor diagnoses (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093976). HO was defined by incident obesity and validated based on incident diabetes insipidus diagnoses and desmopressin prescription within a 12\u2010month period after surgery\/radiotherapy. Uncertainty due to algorithm definitions is explored in sensitivity analyses. Estimated annual incidence of TTR\u2010HO in Germany is between 0.7 and 1.7 cases per 1,000,000 persons (2019 prevalence:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091262 patients). With observed cases in all age groups, two HO\u2010incidence peaks are identified: children\/young adults aged 10\u201324\u2009years and adults aged 40\u201344\u2009years. Most frequent HO\u2010validated tumor diagnoses are benign sellar\/suprasellar tumors (6.1\/1,000,000 persons over 9\u2009years), including tumors of the craniopharyngeal duct (1.3\/1,000,000), neoplasms of the pituitary gland (4.1\/1,000,000), and nonspecific brain tumors of endocrine glands (2.4\/1,000,000). This is the first real\u2010world database analysis of TTR\u2010HO epidemiology, refining current estimates of HO epidemiology and early patient identification. A more comprehensive characterization of patients with HO as well as a better understanding of clinical implications will be crucial in developing optimal treatment strategies to improve patient outcomes.\n                  <\/jats:p>","DOI":"10.1111\/jne.13439","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T20:48:42Z","timestamp":1724791722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hypothalamic obesity: Epidemiology in rare sellar\/suprasellar tumors\u2014A German claims database analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-323X","authenticated-orcid":false,"given":"Julian","family":"Witte","sequence":"first","affiliation":[{"name":"Vandage GmbH  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-0907","authenticated-orcid":false,"given":"Bastian","family":"Surmann","sequence":"additional","affiliation":[{"name":"Vandage GmbH  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-965X","authenticated-orcid":false,"given":"Manuel","family":"Batram","sequence":"additional","affiliation":[{"name":"Vandage GmbH  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5641-6881","authenticated-orcid":false,"given":"Markus","family":"Weinert","sequence":"additional","affiliation":[{"name":"Vandage GmbH  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Flume","sequence":"additional","affiliation":[{"name":"Gene Access GmbH  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6131-8983","authenticated-orcid":false,"given":"Nicolas","family":"Touchot","sequence":"additional","affiliation":[{"name":"Rhythm Pharmaceuticals, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-5496","authenticated-orcid":false,"given":"Julia","family":"Beckhaus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology University Children's Hospital, Carl von Ossietzky University, Klinikum Oldenburg A\u00f6R  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology University Children's Hospital, Carl von Ossietzky University, Klinikum Oldenburg A\u00f6R  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-9966","authenticated-orcid":false,"given":"Hermann L.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology University Children's Hospital, Carl von Ossietzky University, Klinikum Oldenburg A\u00f6R  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100125\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201059602\u20104.00016\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496564"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010022\u201001900\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004\u20101874"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000351\u2010z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21067"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20100174"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003\u2010031751"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010005\u20101166\u20109"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2020.05.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201012\u20100792"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov044"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.052241"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12076"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22315"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31280\u20101"},{"key":"e_1_2_10_19_1","unstructured":"Bundesministerium f\u00fcr Gesundheit.Mitglieder und Versicherte der Gesetzlichen Krankenversicherung (GKV): Statistik uber Versicherte gegliedert nach Status Alter Wohnort und Kassenart; 2020. 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