{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:30:42Z","timestamp":1784169042344,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007431","name":"Neurosciences Research Foundation","doi-asserted-by":"publisher","award":["64756"],"award-info":[{"award-number":["64756"]}],"id":[{"id":"10.13039\/100007431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001343","name":"University of Pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001338","name":"University of Capetown","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The naked mole\u2010rat (<jats:italic>Heterocephalus glaber<\/jats:italic>) is a unique model mammal in which to study socially induced inhibition of the hypothalamic\u2013pituitary\u2013gonadal (HPG) axis. Naked mole\u2010rat groups exhibit a high degree of reproductive bias in which breeding is restricted to one female (the queen) and one male, with subordinate non\u2010breeding colony members rarely, if ever, having the opportunity to reproduce due to a dysfunctional HPG axis. It is posited that aggression directed at subordinates by the queen suppresses reproduction in these subordinates, yet the underlying physiological mechanisms causing this dysfunction are unknown. This study aimed to investigate the possible factors contributing to the dysfunction of the HPG axis in subordinate female naked mole\u2010rats with a specific focus on the role of ovarian feedback and stress\u2010related factors such as circulating glucocorticoid and endogenous opioid peptides. The results showed that stress\u2010related factors appear to not mediate the suppression of reproductive function in subordinate female naked mole rats. Indeed, in some cases, the activation of the stress axis may lead to reproductive activation instead of deactivation. At the same time, the role of ovarian sex steroid feedback in reproductive suppression is likely limited and not clearly delineated. This study highlights the need for detailed studies to elucidate the mechanism of reproductive suppression in this unique model mammalian species which may shed light on, and reveal novel mechanisms, in the social regulation of reproduction.<\/jats:p>","DOI":"10.1111\/jne.13444","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:08:48Z","timestamp":1726470528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The curious case of the hypothalamic\u2013pituitary\u2013gonadal axis dysfunction in subordinate female naked mole\u2010rats (<i>Heterocephalus glaber<\/i>): No apparent role of opioids and glucocorticoids"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-558X","authenticated-orcid":false,"given":"Daniel W.","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Zoology and Entomology University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Zoology University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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