{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:57Z","timestamp":1772160717949,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["F32HD108873"],"award-info":[{"award-number":["F32HD108873"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K23HD097296"],"award-info":[{"award-number":["K23HD097296"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50HD104224"],"award-info":[{"award-number":["P50HD104224"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD096324"],"award-info":[{"award-number":["R01HD096324"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R37HD043341"],"award-info":[{"award-number":["R37HD043341"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE031452"],"award-info":[{"award-number":["R01DE031452"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pubertal timing is a highly heritable trait in the general population. Recently, a large\u2010scale exome\u2010wide association study has implicated rare variants in six genes (\n                    <jats:italic>KDM4C<\/jats:italic>\n                    ,\n                    <jats:italic>MC3R<\/jats:italic>\n                    ,\n                    <jats:italic>MKRN3<\/jats:italic>\n                    ,\n                    <jats:italic>PDE10A<\/jats:italic>\n                    ,\n                    <jats:italic>TACR3<\/jats:italic>\n                    , and\n                    <jats:italic>ZNF483<\/jats:italic>\n                    ) as genetic determinants of pubertal timing within the general population. Two of the genes (\n                    <jats:italic>TACR3<\/jats:italic>\n                    ,\n                    <jats:italic>MKRN3<\/jats:italic>\n                    ) are already implicated in extreme disorders of pubertal timing. This observation suggests that there may be a pervasive \u201cgenetic risk continuum\u201d wherein genes that govern pubertal timing in the general population, by extension, may also be causal for rare Mendelian disorders of pubertal timing. Hence, we hypothesized that the four novel genes linked to pubertal timing in the population will also contribute to idiopathic hypogonadotropic hypogonadism (IHH), a genetic disorder characterized by absent puberty. Exome sequencing data from 1322 unrelated IHH probands were reviewed for rare sequence variants (RSVs) (minor allele frequency bins: &lt;1%; &lt;0.1%; &lt;0.01%) in the six genes linked to puberty in the general population. A gene\u2010based rare variant association testing (RVAT) was performed between the IHH cohort and a reference public genomic sequences repository\u2014the Genome Aggregation Database (gnomAD). As expected, RVAT analysis showed that RSVs in\n                    <jats:italic>TACR3<\/jats:italic>\n                    , a known IHH gene, were significantly enriched in the IHH cohort compared to gnomAD cohort across all three MAF bins. However, RVAT analysis of the remaining five genes failed to show any RSV enrichment in the IHH cohort across all MAF bins. Our findings argue strongly against a pervasive genetic risk continuum between pubertal timing in the general population and extreme pubertal phenotypes. The biologic basis of such distinct genetic architectures' merits further evaluation.\n                  <\/jats:p>","DOI":"10.1111\/jne.13445","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T22:09:41Z","timestamp":1726006181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lack of a genetic risk continuum between pubertal timing in the general population and idiopathic hypogonadotropic hypogonadism"],"prefix":"10.1111","volume":"36","author":[{"given":"Lacey","family":"Plummer","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-5585","authenticated-orcid":false,"given":"Ravikumar","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Stamou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Campbell","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranav","family":"Dewan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Bryant","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Salnikov","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine Massachusetts General Hospital  Boston Massachusetts 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