{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:42:19Z","timestamp":1791837739220,"version":"4.3.4"},"reference-count":175,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ22H270002"],"award-info":[{"award-number":["LQ22H270002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104756"],"award-info":[{"award-number":["82104756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is a highly prevalent and heterogeneous disease characterized by a combination of reproductive and endocrine abnormalities, often associated with metabolic and mental health disorders. The etiology and pathogenesis of PCOS remain unclear, but recent research has increasingly focused on the upstream mechanisms underlying its development. Among these, kisspeptin (KISS) signaling has emerged as a pivotal component in the regulation of the hypothalamic\u2013pituitary\u2013gonadal axis, with significant roles in reproductive function, energy regulation, and metabolism. Women with PCOS commonly exhibit disruptions in gonadotropin secretion, including elevated luteinizing hormone (LH) levels, imbalanced LH\/follicle\u2010stimulating hormone (FSH) ratios, and increased androgen levels, all of which are usually parallel with abnormal KISS signaling. Furthermore, alterations in the KISS\/KISS1R system within the central and circulatory systems, as well as peripheral tissues, have been implicated in the development of PCOS. These changes affect multiple pathophysiological domains, including reproductive function, energy regulation, metabolic homeostasis, inflammatory response, and emotional disorders, and are further influenced by lifestyle and environmental factors. This review aims to comprehensively summarize the existing experimental and clinical evidence supporting these roles of KISS in PCOS, with the goal of establishing a foundation for future research and potential clinical applications.<\/jats:p>","DOI":"10.1111\/jne.13482","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:10:01Z","timestamp":1734577801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiple effects of kisspeptin on neuroendocrine, reproduction, and metabolism in polycystic ovary syndrome"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-1872","authenticated-orcid":false,"given":"Qiaorui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gynecology Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiao","family":"Jia","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tao","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Department of Gynecology Shanghai Guanghua Hospital of Integrative Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenliang","family":"Fan","sequence":"additional","affiliation":[{"name":"Nephrology Department The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Zhejiang China"},{"name":"Academy of Chinese Medical Science Zhejiang Chinese Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.7.4105"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa018"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2022.108989"},{"issue":"4","key":"e_1_2_12_6_1","first-page":"1158","article-title":"Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries","volume":"79","author":"Gilling\u2010Smith C","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1273542"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2606"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab422"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110561"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.2001.0219"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126948"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.2.7956"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.05.008"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.014"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0323"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0022"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2022.111577"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713897114"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00597"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009156118"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3492"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.23.1731"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/35079135"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml023"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.07.008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102743200"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104847200"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493406"},{"issue":"1","key":"e_1_2_12_30_1","first-page":"37","article-title":"Expression of the anti\u2010Mullerian hormone, kisspeptin 1, and kisspeptin 1 receptor in polycystic ovary syndrome and controlled ovarian stimulation rat models","volume":"20","author":"Risvanli A","year":"2020","journal-title":"Bosn J Basic Med Sci"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.01.005"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6237141"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035322"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02333.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/EN.2015-1412"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-05.2005"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0787"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1296129"},{"issue":"3","key":"e_1_2_12_40_1","article-title":"The role of Kisspeptin in female reproduction","volume":"15","author":"Zeydabadi Nejad S","year":"2017","journal-title":"Int J Endocrinol Metab"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.108555"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179229"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0488"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.18146"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1540"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod51.1.125"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa013"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0142"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12227"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12235"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.072298"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1261"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704114104"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0078"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10100988"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108322442"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbaexp.2004.02.005"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab287"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex357"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14899"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71075"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302598RR"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2514-0"},{"issue":"19","key":"e_1_2_12_64_1","first-page":"5993","article-title":"Obesity is associated with increased level of kisspeptin in mothers' blood and umbilical cord blood \u2010 a pilot study","volume":"25","author":"Pruszy\u0144ska\u2010Oszma\u0142ek E","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1257248"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1969"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-21-0169"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2021.11.010"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0583-4"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2010.485254"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719117749761"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2256"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01243"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0823"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0541"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1609"},{"issue":"2","key":"e_1_2_12_77_1","first-page":"367","article-title":"Kisspeptin in the hypothalamus of 2 rat models of polycystic ovary syndrome","volume":"158","author":"Osuka S","year":"2017","journal-title":"Endocrinology"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308058101"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0306-21.2021"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00137"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab158"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13058"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1887"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415038112"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.04.006"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0035-5"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab197"},{"issue":"8","key":"e_1_2_12_88_1","first-page":"767","article-title":"The advancement of the onset of vaginal opening in female rats subjected to chronic testosterone treatment occurs independently of hypothalamic Kiss1 and Rfrp expression","volume":"36","author":"Iwasa T","year":"2015","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-016-9807-0"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.131631"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16-0282"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4509-3"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1338-7"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90895.2008"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-019-00085-6"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118818899"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.01.029"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12823"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00298"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1609-1"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060776"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1379499"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD11118"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.12.008"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1110"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12056"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2017.64.15.2"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD21230"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/0964528420971299"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2015.1120745"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.05.049"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0457-z"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy046"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-15-0252"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.021"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2015.08.014"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1501"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110559"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166242"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03191-9"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90377.2008"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02817-2"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21935"},{"key":"e_1_2_12_124_1","article-title":"Prenatal undernutrition affects the phenotypes of PCOS model rats","volume":"8","author":"Iwasa T","year":"2018","journal-title":"J Endocrinol"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1415"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-017-0530-y"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0181"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.03.001"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22795"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.146"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0054"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32834558df"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1819339"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504225"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00698-0"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0711"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.11.018"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.06.004"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.11.044"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1597343"},{"key":"e_1_2_12_141_1","first-page":"34","article-title":"Effect of kisspeptin on pathogenesis and energy metabolism of polycystic ovary syndrome","volume":"26","author":"Guo S","year":"2018","journal-title":"Chin J Family Plann"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.04.017"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.665446"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.10.011"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111042"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901600R"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00209"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.747944"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.744628"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0068"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.108777"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1177\/09645284211056663"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345620"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.06.007"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1811964"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0736"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.709674"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex044"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.928143"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.11.039"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481137"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00438-1"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2010"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13479"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2023.2241902"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23380"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00044"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2020.61.55"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.02.066"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00273"},{"issue":"3","key":"e_1_2_12_171_1","first-page":"225","article-title":"Effects of melatonin administration on chemical pregnancy rates of polycystic ovary syndrome patients undergoing intrauterine insemination: a randomized clinical trial","volume":"13","author":"Mokhtari F","year":"2019","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5570"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11090789"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.116154"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116683808"},{"issue":"5","key":"e_1_2_12_176_1","first-page":"2219","article-title":"Is there an association between circulating Kisspeptin levels and ovarian Reserve in Women of reproductive age?","volume":"37","author":"Nikolettos K","year":"2023","journal-title":"In Vivo (Athens, Greece)"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:25:56Z","timestamp":1744266356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":175,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/jne.13482"],"URL":"https:\/\/doi.org\/10.1111\/jne.13482","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13482"}}