{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:56Z","timestamp":1772160716670,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Data on the risk of stroke in patients with hyperprolactinemia are limited. This study aimed to evaluate the association between hyperprolactinemia and ischemic stroke in a large cohort and identify predictors of stroke in this population. This was a retrospective cohort study comparing the incidence of ischemic stroke in patients with dopamine agonist\u2010treated hyperprolactinemia to matched controls in a 1:5 ratio. The primary outcome was the diagnosis of ischemic stroke. The cohort included 2440 patients with DA\u2010treated hyperprolactinemia patients (mean age\u2009\u00b1\u2009SD: 38.42\u2009\u00b1\u200914.57\u2009years, 60.2% women) matched to 12,022 controls (mean age\u2009\u00b1\u2009SD: 38.15\u2009\u00b1\u200914.36\u2009years, 60.8% women). Ischemic stroke occurred in 195 patients with hyperprolactinemia (8.0%) and 747 controls (6.21%) (adjusted HR 1.24, 95% CI 1.06\u20131.46). Patients with hyperprolactinemia developed stroke at a younger age (57.75\u2009\u00b1\u200915.88\u2009years vs. 60.18\u2009\u00b1\u200915.20\u2009years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.05). Patients with PRL levels &gt;5\u00d7 ULN at diagnosis had a higher stroke incidence than those with lower levels (9.73% vs. 6.85%; HR 1.48, 95% CI 1.11\u20131.97). Longer time to prolactin normalization was associated with a higher incidence of stroke (median 21.88 vs. 13.78\u2009months;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0005). In multivariate analysis, age \u226560\u2009years, male gender, hypertension, type 1 or type 2 diabetes mellitus, and ischemic heart disease were significant predictors of stroke in patients with hyperprolactinemia. Dopamine agonist\u2010treated hyperprolactinemia is associated with an increased risk of ischemic stroke compared to well\u2010matched controls from the general population. Higher prolactin levels at diagnosis and a longer time to normalization were linked to a greater risk of stroke.\n                  <\/jats:p>","DOI":"10.1111\/jne.13494","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:29:16Z","timestamp":1739251756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ischemic stroke risk in patients with dopamine agonist\u2010treated hyperprolactinemia"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-344X","authenticated-orcid":false,"given":"Amit","family":"Akirov","sequence":"first","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Endocrinology, Rabin Medical Center Beilinson Hospital  Petah Tikva 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