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The pathogenesis of these tumors remains incompletely understood, although accumulating evidence suggests that the activation of the cellular senescence program, triggered by various stressors and functioning as a brake on cellular proliferation, may contribute to their typically benign nature. Multiple mediators of the senescence response are implicated in this process. Interleukin\u20106 (IL\u20106), a proinflammatory cytokine, plays a dual role in pituitary tumor biology. It is involved in both physiological pituitary growth and the senescence\u2010associated secretory phenotype (SASP), where it mediates paracrine\u2010proliferative signals. In addition to its secretory functions, IL\u20106 has been implicated in the regulation of pituitary senescence through non\u2010secretory mechanisms. Other factors, such as growth hormone (GH), the pituitary tumor\u2010transforming gene (PTTG), and interactions within the tumor microenvironment, including immune cell dynamics, also contribute to the senescence observed in these tumors. This review examines the latest evidence concerning the role of senescence in pituitary tumors, with a particular focus on the contribution of IL\u20106 to this process.<\/jats:p>","DOI":"10.1111\/jne.70008","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:34:37Z","timestamp":1741739677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New insights in cellular senescence: The pituitary model"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-3083","authenticated-orcid":false,"given":"Florencia","family":"Herbstein","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Biomedicina de Buenos Aires (IBioBA) \u2013 CONICET \u2013 Partner Institute of the Max Planck Society  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Rosmino","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Endocrinolog\u00eda Hospital General de Agudos \u201cCarlos G. 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