{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:32:27Z","timestamp":1780918347606,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022718","name":"Anneliese Pohl Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO325"],"award-info":[{"award-number":["KFO325"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Non\u2010functioning pancreatic neuroendocrine tumors (NF\u2010pNETs) significantly contribute to the premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers are not yet available. MicroRNAs (miRNA) and long\u2010non\u2010coding (lnc) RNAs, transported by extracellular vesicles, are emerging as new prognostic tools. This study aimed to analyze the clinical characteristics, the exosomal\u2010miRNA 451 (exo\u2010miR451) and the lnc\u2010RNA nuclear paraspeckle assembly transcript 1 (NEAT1_1, 3.7\u2009kB) in the mild and aggressive courses of MEN1\u2010NFpNET disease. Patient characteristics were assessed regarding an aggressive course of disease. In addition, exo\u2010miR451 and exo\u2010lnc\u2010NEAT1_1 expression levels were quantified in serum by RT\u2010qPCR and correlated with clinical data. Immunohistochemistry results of STAT3 (signal transducer and activator of transcription 3), regulated by NEAT1, were performed in NF\u2010pNET tissue and correlated with exo\u2010lnc\u2010NEAT1_1 expression. Among 66 MEN1 patients with NF\u2010pNETs, 13 (20%) had an aggressive disease course. No significant differences in patient characteristics were observed between those with aggressive (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) and mild (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200953) disease (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.5). Exosomal miRNA\u2010451 was dysregulated in 55% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923) of cases, showing a trend toward higher upregulation in the aggressive group (36% vs. 19%), although this difference was not statistically significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.215). Exo\u2010NEAT1_1 was overexpressed in 42% (16\/38) of patients, without significant differences between groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0523). However, exo\u2010NEAT1_1 expression strongly correlated with STAT3 immunohistochemical staining (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001). Although no prognostic marker could be identified, we show for the first time that the STAT3\u2010NEAT1 pathway plays a role in MEN1\u2010associated NF\u2010pNET tumorigenesis.\n                  <\/jats:p>","DOI":"10.1111\/jne.70024","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:29:13Z","timestamp":1743730153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of clinical parameters and exosomal\n                    <scp>lncRNA NEAT1_1<\/scp>\n                    in\n                    <scp>MEN1<\/scp>\n                    \u2010related non\u2010functioning pancreatic neuroendocrine tumors"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-2712","authenticated-orcid":false,"given":"Jerena","family":"Manoharan","sequence":"first","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Albers","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Khizanishvili","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Krasser\u2010Gercke","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Pathology Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Mintziras","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"W\u00e4chter","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-2915","authenticated-orcid":false,"given":"Anja","family":"Rinke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Endocrinology, University Hospital Marburg Philipps University Marburg  Marburg 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