{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:49:14Z","timestamp":1792180154736,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008605","name":"Indian National Science Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Abstract<\/jats:title>\n \n Illuminated nights reduce melatonin peak and disrupt sleep. Using this as the basis of the present experimental paradigm, we investigated whether nocturnal melatonin levels were crucial for sleep regulation in a diurnal vertebrate. Acclimated Indian house crows (\n Corvus splendens<\/jats:italic>\n ) were randomly segregated into three groups of 12 each. For the next 10\u2009days, one group was maintained on 12\u2009L:12 D, as before (LD control); for the other two groups, the absolute darkness was replaced with dim light at night (dLAN; L\u2009=\u2009~150 lux, D\u2009=\u2009~6 lux). Under dLAN, half an hour before light off time, the LD control and one dLAN group received intraperitoneally 200\u2009\u03bcL of vehicle (0.75% physiological saline), while the other dLAN group received a similar 200\u2009\u03bcL vehicle but containing melatonin at a dose of 50\u2009\u03bcg bird\n \u22121<\/jats:sup>\n \u2009day\n \u22121<\/jats:sup>\n . Under dLAN, exogenous melatonin elevated nocturnal\n AANAT<\/jats:italic>\n mRNA and plasma melatonin levels and induced changes in diurnal expressions of clock genes (\n PER2<\/jats:italic>\n ,\n CRY1<\/jats:italic>\n ,\n BMAL1<\/jats:italic>\n ,\n NPAS2<\/jats:italic>\n ,\n REVERB<\/jats:italic>\n ) in the pineal gland and hypothalamus, and of genes encoding melatonin receptors (\n MEL1a<\/jats:italic>\n ,\n MEL1b<\/jats:italic>\n ) and epigenetic modifiers (\n HAT1<\/jats:italic>\n ,\n HDAC2<\/jats:italic>\n ,\n HDAC4<\/jats:italic>\n ,\n DNMT3a<\/jats:italic>\n ) in the hypothalamus. Elevated nocturnal melatonin levels bettered sleep with positive effects on the hypothalamic expression of genes associated with nocturnal sleep (cytokine pathway:\n TLR4<\/jats:italic>\n ,\n TNF\u03b1<\/jats:italic>\n ,\n IL\u20101\u03b2<\/jats:italic>\n ,\n NOS1<\/jats:italic>\n ; calcium pathway:\n CAMK2<\/jats:italic>\n ,\n SIK3<\/jats:italic>\n ) and awake (\n ACHM3<\/jats:italic>\n ,\n EGR1<\/jats:italic>\n ,\n HOMER1a<\/jats:italic>\n ,\n OREXIN<\/jats:italic>\n ) states, and with neurogenesis and synaptic plasticity (\n BDNF<\/jats:italic>\n ,\n EGR1<\/jats:italic>\n ,\n CREB<\/jats:italic>\n ). These suggested the role of melatonin in mitigation of the dLAN\u2010induced sleep disruption. Nocturnal melatonin peak levels are a crucial component of the regulatory transcriptional pathways underlying the daily wake\u2013sleep pattern, with far\u2010reaching implications for sleep\u2010related issues in diurnal species including perhaps humans inhabiting an over\u2010lit environment with pervasive light pollution.\n <\/jats:p>","DOI":"10.1111\/jne.70035","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:29:39Z","timestamp":1745447379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of melatonin in physiological mitigation of sleep disruption in an unnatural temporal environment"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-2471","authenticated-orcid":false,"given":"Amaan","family":"Buniyaadi","sequence":"first","affiliation":[{"name":"IndoUS Centre in Chronobiology, Department of Zoology University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-5519","authenticated-orcid":false,"given":"Abhilash","family":"Prabhat","sequence":"additional","affiliation":[{"name":"IndoUS Centre in Chronobiology, Department of Zoology University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-2607","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Zoology C.C.S. University Meerut Meerut India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-8689","authenticated-orcid":false,"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"IndoUS Centre in Chronobiology, Department of Zoology University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-6552-9_6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09291010412331313287"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600377"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10336-015-1196-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7120\/09627286.22.4.483"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2238"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14157"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.07.084"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2019.2952"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2022.0514"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1993.tb00502.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113278"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1995.tb00135.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.10.002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.13756"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.119618"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80350-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00230.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2018.07.004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51791-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.5665\/SLEEP.1274"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2741\/1033"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2521"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0121"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.01.050"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061155"},{"key":"e_1_2_11_28_1","first-page":"215","volume-title":"Integration of comparative neuroanatomy and cognition","author":"Izawa EI","year":"2007"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.12.016"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2023.105353"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.1531"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/clockssleep3010008"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.07.028"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1150-08.2008"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026622"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa0069"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.144667"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00114"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1937-6"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.120"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32833eec92"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2022.113866"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-008-0036-9"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121467"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0025-1"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00188"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00087"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1174"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.07.019"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2016.05.004"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T23:28:03Z","timestamp":1755473283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jne.70035"],"URL":"https:\/\/doi.org\/10.1111\/jne.70035","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.70035\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.70035\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.70035\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.70035\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.70035\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"assertion":[{"value":"2024-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70035"}}