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CART\u2010expressing MCH cells densely innervate the lateral septum (LS), which integrates food\u2010 and mood\u2010related behaviours. However, while MCH typically promotes feeding and anxiolysis, CART suppresses feeding and promotes anxiogenesis. The LS is a target site of orexigenic MCH actions, but it is not known if the actions of CART converge or oppose that of MCH in the LS. We implanted a bilateral cannula over the lateral or medial LS of male and female wildtype mice and infused vehicle, CART\n                    <jats:sub>55\u2013102<\/jats:sub>\n                    , MCH, or CART\u2009+\u2009MCH. We then assessed the intake of a standard chow diet or palatable high sugar diet over 4\u2009h, as well as anxiety\u2010like behaviour via the open\u2010field test. In both male and female mice, intra\u2010LS CART infusion alone did not produce anorexigenic effects. However, CART infusion diminished MCH\u2010mediated feeding, especially via the lateral LS. By contrast, intra\u2010LS CART infusion reduced time spent in the centre of an open field in male but not female mice. Our findings indicated that CART elicited anorectic effects in the presence of MCH, but CART independently produced anxiogenic effects. These outcomes suggested that putative CART and MCH co\u2010release from MCH neurons may provide biphasic regulation of feeding and anxiety.\n                  <\/jats:p>","DOI":"10.1111\/jne.70055","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:41:04Z","timestamp":1750149664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anorectic and anxiogenic actions of cocaine\u2010 and amphetamine\u2010regulated transcript in the lateral septum"],"prefix":"10.1111","volume":"37","author":[{"given":"Anjali","family":"Shankhatheertha","sequence":"first","affiliation":[{"name":"Department of Neuroscience Carleton University  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla A.","family":"Payant","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Carleton University  Ottawa Ontario 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