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In adults, impairments in neurogenesis commonly associate with anxiety and depressive behaviors. Insulin\u2010like growth factor 2 (IGF2) is expressed in the choroid plexus (CP) within the subventricular zone (SVZ) neurogenic niche, and global loss of IGF2 leads to increased anxiety. Previously, we have shown that\n                    <jats:italic>Igf2<\/jats:italic>\n                    expression in CP tissue increases 6\u2010fold during lactation but returns to baseline on suppression of prolactin present in lactation, suggesting it is induced by high levels of prolactin. To gain more insight into the role of prolactin\u2010induced\n                    <jats:italic>Igf2<\/jats:italic>\n                    expression in the CP, we have measured IGF2 levels in cerebrospinal fluid across reproductive states and developed mice in which\n                    <jats:italic>Igf2<\/jats:italic>\n                    is conditionally removed from the CP. Using CP\u2010derived IGF2 knockout mouse models, we have measured\n                    <jats:italic>Prlr<\/jats:italic>\n                    expression in CP tissue, SVZ mitogenesis, olfaction, and anxiety\u2010like behavior using an elevated plus maze (EPM) and light\/dark transition test (LDTT). Interestingly, we observed a reduction in\n                    <jats:italic>Prlr<\/jats:italic>\n                    expression in CP tissue in one of our\n                    <jats:italic>Igf2<\/jats:italic>\n                    knockout mouse models, suggesting\n                    <jats:italic>Igf2<\/jats:italic>\n                    may also act upstream to regulate\n                    <jats:italic>Prlr<\/jats:italic>\n                    expression in CP tissue. No changes were detected in SVZ proliferation rates between\n                    <jats:italic>Igf2<\/jats:italic>\n                    knockout and controls. Using a buried food test (BFT), however, we show mice with conditional loss of\n                    <jats:italic>Igf2<\/jats:italic>\n                    in the CP take longer to find a buried fruit loop as compared to controls, indicating olfaction deficits. Overall anxiety levels, however, were comparable between knockout and controls in the EPM and LDTT. Together, our findings reveal loss of CP\u2010derived IGF2 leads to hyposmia in the absence of detectable changes to SVZ mitogenesis. We propose that CP\u2010derived IGF2 may be acting directly in the olfactory bulb to elicit changes to improve olfaction, which may become particularly important during the post\u2010partum period to facilitate mother\u2013pup interactions.\n                  <\/jats:p>","DOI":"10.1111\/jne.70058","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:29:23Z","timestamp":1748921363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Loss of choroid plexus\u2010derived insulin\u2010like growth factor 2 (\n                    <scp>IGF2<\/scp>\n                    ) leads to hyposmia, while retaining post\u2010partum mood resilience in mice"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-0758","authenticated-orcid":false,"given":"Hollian R.","family":"Phillipps","sequence":"first","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy School of Biomedical Sciences, University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0884-8774","authenticated-orcid":false,"given":"Eleni C. R.","family":"Hackwell","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy School of Biomedical Sciences, University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-4269","authenticated-orcid":false,"given":"Ionel","family":"Sandovici","sequence":"additional","affiliation":[{"name":"University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit Institute of Metabolic Science, Addenbrookes Hospital  Cambridge UK"},{"name":"Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre  Cambridge UK"},{"name":"Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience University of Cambridge  Cambridge 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Dunedin New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery University of Auckland  Auckland New 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