{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:51Z","timestamp":1772160711487,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Health\u2010related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ\u2010C30 and GI.NET21. We used Cox proportional hazards to calculate the hazard ratio (HR) of survival according to the QLQ\u2010C30 summary score, adjusting for clinical variables selected with causal inference. Flexible parametric modelling using cubic splines was used to illustrate the time\u2010dependent relationship between HRQoL and OS. The QLQ\u2010C30 summary score was correlated with overall survival (OS) with an adjusted HR of 0.62 (95% CI 0.46\u20130.83,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) for each 10\u2010point increase in summary score. Compared to a model using only clinical variables, the summary score increased predictive accuracy by eight percentage units and improved model fit. The inclusion of GI.NET21 with the summary score yielded similar results. HRQoL predicts overall survival in patients with siNET, providing additional information to clinical variables. Measuring HRQoL might be useful when following patients with siNET.\n                  <\/jats:p>","DOI":"10.1111\/jne.70081","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:22:51Z","timestamp":1755044571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life as a predictor for survival in patients with small intestinal neuroendocrine tumours"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-3727","authenticated-orcid":false,"given":"H\u00e5kan","family":"Ohlsson","sequence":"first","affiliation":[{"name":"Department of Surgery Ystad Hospital  Ystad Sweden"},{"name":"Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Endocrine\u2010Sarcoma Unit, Department of Surgery Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sundl\u00f6v","sequence":"additional","affiliation":[{"name":"Medical Oncology, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Malmstr\u00f6m","sequence":"additional","affiliation":[{"name":"The Institute for Palliative Care Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Health Sciences Lund University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Almquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Endocrine\u2010Sarcoma Unit, Department of Surgery Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000037481.36604.eb"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0100-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-006-0003-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70200-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.208"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31556"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-21-0354"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3189-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2015.002980"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000818"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i25.3686"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.560"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.10.026"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-0082-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.08.007"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.5865"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499469"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.12.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13139"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06146-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_11_23_1","volume-title":"EORTC QLQ\u2010C30 scoring manual","author":"Fayers P","year":"2001"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2202\/1557-4679.1203"},{"key":"e_1_2_11_27_1","volume-title":"Disposable Income Per Consumption Unit in Relation to Median Income, by Grounds for Residence, Duration of Residence, Region of Birth, and Age. 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