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Diagnostic tests for AVP\u2010D are limited by low accuracy and\/or tolerability. Kisspeptin (KP) stimulates AVP release in animals, but no study has investigated KP as a provocative test for AVP\u2010D in humans. We investigated circulating AVP levels in response to intravenous (IV) KP in adults. We also explored sex differences in AVP response to KP. Twelve healthy adults (50% female) received an IV KP bolus. Serum AVP was measured pre\u2010 and 10, 20, 40, and 60 min post\u2010KP. AVP levels were higher in males at all time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.028) and did not change in response to KP. KP did not stimulate AVP, possibly due to dose, administration route, or cross\u2010species differences in the AVP system. Our study does not support IV KP bolus of 0.24\u2009nmol\/kg as a provocative test for AVP\u2010D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>Our study was registered on ClinicalTrials.gov (NCT00914823).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jne.70114","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:13:51Z","timestamp":1763799231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravenous kisspeptin 112\u2013121 bolus does not acutely impact circulating vasopressin in humans"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-2541","authenticated-orcid":false,"given":"Francesca","family":"Galbiati","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Faculty of Medicine University of Vic\u2010Central University of Catalonia (UVic\u2010UCC), Vic\/Manresa  Catalonia Spain"},{"name":"Division of Endocrinology, Diabetes, and Hypertension Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Plessow","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacey","family":"Plummer","sequence":"additional","affiliation":[{"name":"Reproductive Endocrine Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark B.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Reproductive Endocrine Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwan","family":"Nazarloo","sequence":"additional","affiliation":[{"name":"Kinsey Institute Indiana University  Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Sue","family":"Carter","sequence":"additional","affiliation":[{"name":"Kinsey Institute Indiana University  Bloomington Indiana USA"},{"name":"Department of Psychology University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rona S.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts 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