{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:51:42Z","timestamp":1791244302609,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Typical carcinoids (TC) are neuroendocrine malignancies of the lung with low risk of recurrence and a favorable prognosis. It is unclear whether lymph node status and tumor size affect the recurrence risk. Following radical surgery, current guidelines recommend comprehensive follow\u2010up including regular computed tomography (CT) imaging. We aimed to estimate the risk of recurrence in curatively treated patients with TC and to discuss the justification of the current comprehensive follow\u2010up program. We identified all patients diagnosed with TC from 2009 to 2020 at Aarhus University Hospital, Denmark and Copenhagen University Hospital, Rigshospitalet, Denmark. Patients without distant metastases (M0) who underwent radical surgery (R0) were included in the analysis. The risk of recurrence was estimated using the Aalen\u2010Johansen method treating death as a competing risk. Fine\u2010Gray models were used to evaluate the effect of lymph node status and tumor size. Three\u2010hundred and thirty patients were included in the analysis, of whom 40 had lymph node involvement and 290 did not. During a total follow\u2010up time of 2806\u2009years across all patients, with an individual median of 8.1\u2009years (IQR: 5.9\u201311.2), 10 patients had recurrence: four in the node\u2010negative group and six in the node\u2010positive group. The 10\u2010year cumulative risk of recurrence for all patients was 3.4% (95% confidence interval (CI): 1.7\u20136.0), for patients without lymph node involvement 1.6% (95% CI: 0.5\u20133.8), and for patients with lymph node involvement 15.6% (95% CI: 6.3\u201328.8). Of the four recurrences in the node\u2010negative group, one led to re\u2010resection with curative intent. Patients with TC without lymph node involvement have a very low risk of recurrence. Thus, we recommend tailoring the follow\u2010up program based on lymph node status, with node\u2010negative patients being excluded from regular follow\u2010up programs.<\/jats:p>","DOI":"10.1111\/jne.70164","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:36:51Z","timestamp":1773974211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Follow\u2010up is not justified in patients with typical lung carcinoids without lymph node involvement treated with curative intent: A Danish Multi\u2010ENETS Center of Excellence Study"],"prefix":"10.1111","volume":"38","author":[{"given":"Tobias Stemann","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"ENETS Center of Excellence Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Soldath","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Rigshospitalet  Copenhagen Denmark"},{"name":"ENETS Center of Excellence Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Stubkj\u00e6r","family":"Rewitz","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"ENETS Center of Excellence Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"ENETS Center of Excellence Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Knigge","sequence":"additional","affiliation":[{"name":"ENETS Center of Excellence Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Gastrointestinal Surgery Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Nephrology and Endocrinology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo W.","family":"Langer","sequence":"additional","affiliation":[{"name":"ENETS Center of Excellence Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Oncology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 Horsleben","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Rigshospitalet  Copenhagen Denmark"},{"name":"ENETS Center of Excellence Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Andreassen","sequence":"additional","affiliation":[{"name":"ENETS Center of Excellence Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Nephrology and Endocrinology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Dam","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"ENETS Center of Excellence Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Thoracic Tumours","author":"WHO Classification of Tumours Editorial 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