{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:47:08Z","timestamp":1789577228961,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Digestive neuroendocrine carcinomas (NEC) are rare, aggressive, and treatment\u2010resistant malignancies. Platinum and etoposide are recommended as first line treatment; however, with limited benefit in colorectal NEC and in NEC with low Ki67 of 20%\u201355%. There is no firm evidence for second\u2010line treatment. Being efficient in digestive adenocarcinomas, FOLFIRINOX is sometimes used also in patients with NEC. In this retrospective cohort study, patients with digestive NEC who received FOLFIRINOX and were diagnosed 2014\u20132021 were retrospectively identified at three Scandinavian centers. Histology was re\u2010evaluated according to the 2019 WHO classification to exclude NET G3 tumors. Patient characteristics, treatment response, and survival outcomes were assessed. Fifty cases were identified; four of these were classified as mixed neuroendocrine non\u2010neuroendocrine neoplasm (MiNEN). The most common primary sites were colon (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917) and pancreas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913). FOLFIRINOX was administrated predominantly in later lines (82%). Overall response rate (RR) was 44% (95% confidence interval (CI): 29%\u201358%) and disease control rate 72% (CI: 57%\u201383%), while median progression free survival was 5.6\u2009months (CI: 4.3\u20136.9\u2009months). Twenty\u2010three patients with colorectal primary, 12 patients with Ki67\u2009&lt;\u200955%, and 33 patients previously exposed to platinum and etoposide as first line; the RR was 52%, 50%, and 39%, respectively. This study suggests a role for FOLFIRINOX in digestive NEC. High efficacy was observed, even in patients with hard\u2010to\u2010treat colorectal primaries, in those with Ki67\u2009&lt;\u200955%, and in patients previously exposed to platinum and etoposide.\n                  <\/jats:p>","DOI":"10.1111\/jne.70168","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:09:06Z","timestamp":1774915746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of\n                    <scp>FOLFIRINOX<\/scp>\n                    in digestive neuroendocrine carcinoma"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5895-2181","authenticated-orcid":false,"given":"B. P.","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Oncology, Cancer Clinic Oslo University Hospital  Oslo Norway"},{"name":"ENETS Neuroendocrine Tumor Centre of Excellence Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-6214","authenticated-orcid":false,"given":"H.","family":"Sorbye","sequence":"additional","affiliation":[{"name":"Cancer Clinic Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Science University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-1228","authenticated-orcid":false,"given":"M.","family":"Ladekarl","sequence":"additional","affiliation":[{"name":"Department of Oncology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-0340","authenticated-orcid":false,"given":"H. L.","family":"Stokmo","sequence":"additional","affiliation":[{"name":"ENETS Neuroendocrine Tumor Centre of Excellence Oslo University Hospital  Oslo Norway"},{"name":"The Intervention Centre Oslo University Hospital  Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Radiology Vestre Viken Hospital  Drammen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M. B.","family":"Lothe","sequence":"additional","affiliation":[{"name":"Department of Pathology Oslo University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fawad","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Tabaksblat","sequence":"additional","affiliation":[{"name":"ENETS Neuroendocrine Tumor Centre of Excellence Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Revheim","sequence":"additional","affiliation":[{"name":"ENETS Neuroendocrine Tumor Centre of Excellence Oslo University Hospital  Oslo Norway"},{"name":"The Intervention Centre Oslo University Hospital  Oslo Norway"},{"name":"Institute for Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dybdahl","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Clinic Oslo University Hospital  Oslo Norway"},{"name":"ENETS Neuroendocrine Tumor Centre of Excellence Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Couvelard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bichat Hospital AP\u2010HP and Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perren","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. O.","family":"Hjortland","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Clinic Oslo University Hospital  Oslo Norway"},{"name":"ENETS Neuroendocrine Tumor Centre of Excellence Oslo University Hospital  Oslo 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