{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T01:33:30Z","timestamp":1777253610260,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lung neuroendocrine tumors (LNETs) are rare, with surgical resection as the mainstay of treatment, although the optimal extent remains uncertain. Herein, we present the first meta\u2010analysis to assess the effect of resection extent (lobar vs. sub\u2010lobar) on overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review of the literature to identify studies comparing overall survival following lobectomy versus sub\u2010lobar resection in LNETs. An inverse\u2010variance meta\u2010analysis was performed, and a Cox regression model was applied to reconstructed time\u2010to\u2010event data estimated from published Kaplan\u2013Meier curves to generate pooled survival estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six studies encompassing 3,700 patients (lobectomy,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092,409; sub\u2010lobar resection,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,291) were included in the final analysis. The pooled 5\u2010year overall survival for the entire cohort was 78.8% (95% CI, 76.6\u201381.1). No statistically significant difference in overall survival was observed between lobectomy and sub\u2010lobar resection (HR\u2009=\u20091.21; 95% CI, 0.80\u20131.83;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =\u20090%). Segmentectomy and lobectomy demonstrated comparable survival (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.38), whereas wedge resection was associated with higher mortality (HR\u2009=\u20092.02; 95% CI, 1.64\u20132.49;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =\u20090%). Sampling of &gt;10 lymph nodes was more frequent in lobectomy than sub\u2010lobar resection (29.1% [95% CI, 0.8\u201395.3] vs 7.4% [95% CI, 0.01\u201398], respectively), likely contributing to the higher rate of nodal pathologic upstaging observed in the lobectomy group (6.2% [95% CI, 0.2\u201364.9] vs 2.2% [95% CI, 0\u201399]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this first meta\u2010analysis of surgical resection for LNETs, sub\u2010lobar resection and lobectomy showed no clear difference in overall survival. Adequate lymph node assessment remains essential, irrespective of the surgical approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jne.70176","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:45:17Z","timestamp":1775097917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The lesser the better? A systematic review and meta\u2010analysis of resection strategy in lung neuroendocrine tumors"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-1195","authenticated-orcid":false,"given":"Gal","family":"Aviel","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8469-8671","authenticated-orcid":false,"given":"Ranin","family":"Hojerat","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam","family":"Idais","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruria","family":"Hirsh\u2010Raccah","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Division of Clinical Pharmacy Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Grozinsky\u2010Glasberg","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumor Unit, ENETS Centre of Excellence, Division of Internal Medicine Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat Bel","family":"Ange","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumor Unit, ENETS Centre of Excellence, Division of Internal Medicine Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oz M.","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Korach","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uzi","family":"Izhar","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Wald","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010018\u20100678\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2012.05.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.01.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212083"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02333\u20103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010022\u201001026\u20103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20102385"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010010\u20109491\u2010z"},{"key":"e_1_2_8_12_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. 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