{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:56Z","timestamp":1777984256637,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Management of appendiceal neuroendocrine tumours (aNET) with a size of 1\u20132 cm is a topic of debate, with the conflict centred on the potential oncological benefits of right hemicolectomy (RHC) versus appendectomy and the impact of RHC on quality of life. A recent study suggested that RHC may not be needed for certain aNET 1\u20132 cm in size. A total of 1244 adult patients with aNET 1\u20132 cm (diagnosed 2012\u20132022) who underwent appendectomy or RHC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Similarly, a total of 270 patients (diagnosed 2012\u20132021) were extracted from the National Cancer Registration and Analysis Service (NCRAS) database. Kaplan\u2013Meier (KM) plots for overall survival (OS) were generated with log\u2010rank tests (LR). Univariable and multivariable Cox regression for all\u2010cause mortality were performed. In the NCRAS cohort, 159 and 111 patients underwent appendectomy and RHC, respectively. The median age was 41 and 51\u2009years for appendectomy and RHC, respectively. Most patients were female (63.7%) and of white race (86.3%). Patients who underwent RHC had a higher proportion of node\u2010positive disease. In the SEER cohort, 957 and 287 patients underwent appendectomy and RHC, respectively. Median age was 39 and 47\u2009years for appendectomy and RHC, respectively. Most patients were females (65.3%) and of white race (67.7%). Patients who underwent RHC had a higher proportion of node\u2010positive disease and M1 stage. Sex and race distribution were similar for the two procedures in both NCRAS and SEER. The KM plot for OS in NCRAS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.061) and SEER (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.14) showed no statistical difference between appendectomy and RHC. Cox regression for all\u2010cause mortality showed that there is no statistical difference between appendectomy and RHC in both cohorts after adjusting for other factors, including age and N stage. Cox regression for all\u2010cause mortality for both cohorts combined showed the same result. Survival of appendectomy is non\u2010inferior to RHC in the management of aNET 1\u20132 cm, even in patients with node\u2010positive disease. These study findings address the gap in current clinical practice guidelines.\n                  <\/jats:p>","DOI":"10.1111\/jne.70179","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:03:55Z","timestamp":1776207835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemicolectomy or appendectomy for appendiceal neuroendocrine tumours sized 1\u20132\u2009cm? A retrospective population\u2010based study of 1514 patients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6779-5589","authenticated-orcid":false,"given":"Ker Shiong","family":"Tan","sequence":"first","affiliation":[{"name":"Medicine Division Hampshire Hospitals NHS Foundation Trust  Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-4164","authenticated-orcid":false,"given":"Aya","family":"Abdelhameed","sequence":"additional","affiliation":[{"name":"Medicine Division Hampshire Hospitals NHS Foundation Trust  Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-2763","authenticated-orcid":false,"given":"Mohamed","family":"Mortagy","sequence":"additional","affiliation":[{"name":"Medicine Division Hampshire Hospitals NHS Foundation Trust  Basingstoke UK"},{"name":"Internal Medicine Department St. George's University School of Medicine  St. George's Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8705-7581","authenticated-orcid":false,"given":"Benjamin E.","family":"White","sequence":"additional","affiliation":[{"name":"Medicine Division Hampshire Hospitals NHS Foundation Trust  Basingstoke UK"},{"name":"Neuroendocrine Centre Kings Health Partners  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-1068","authenticated-orcid":false,"given":"Dan","family":"Burns","sequence":"additional","affiliation":[{"name":"School of Electronics and Computer Science University of Southampton  Southampton UK"},{"name":"NIHR Applied Research Collaboration Wessex University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-6600","authenticated-orcid":false,"given":"John","family":"Ramage","sequence":"additional","affiliation":[{"name":"Medicine Division Hampshire Hospitals NHS Foundation Trust  Basingstoke UK"},{"name":"Neuroendocrine Centre Kings Health Partners  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010295"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010023\u201001093\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(196802)21:2<270::aid\u2010cncr2820210217>3.0.co;2\u20109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712313172704"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21764"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2024.08.001"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002939"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103468(90)90221\u2010t"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13332"},{"key":"e_1_2_12_11_1","unstructured":"National Comprehensive Cancer Network.Neuroendocrine and Adrenal Tumors.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/neuroendocrine.pdf"},{"key":"e_1_2_12_12_1","unstructured":"SoonawallaZ ArmstrongT.Management of NETs of the Appendix. 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