{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:06:27Z","timestamp":1782281187429,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Food\u2010related stimuli can promote feeding behaviors independent of metabolic need. Cue\u2010potentiated feeding (CPF) studies in rodents offer the potential to reveal the psychobiological mechanisms underlying learned overeating behaviors. We examined whether lateral hypothalamic area (LHA) cells expressing the feeding signal Melanin Concentrating Hormone (MCH) are sufficient and necessary for CPF. Tg(Pmch\u2010Cre) mice received bilateral infusion of the Cre\u2010dependent inhibitory DREADD (hM4Di), or optrode placement together with the excitatory opsin ChR2. Mice received food deprivation by restricting access to two daily meal pellets. Once weight reached ~90% from baseline, Pavlovian training commenced, in which a tone or noise conditioned stimulus (CS+) predicted the delivery of a sucrose solution, whereas a second CS\u2212 was unpaired with sucrose delivery. Following a minimum of 2\u2009days of ad\u2010libitum pellet access, mice underwent\u00a0CPF testing, where the amount of licking for sucrose in the presence of the CS+ and CS\u2212 cues was assessed. In both the chemogenetic and optogenetic studies, control mice displayed CPF as evidenced by increased lick rate during the CS+ compared to the CS\u2212. hM4Di\u2010mediated inhibition of LHA MCH cells significantly impaired CPF through disrupting the capacity for the CS+ to increase the mean size of licking bursts, a measure thought to index the orosensory taste properties of sucrose. By contrast, optogenetic stimulation of LHA MCH cells enhanced CPF relative to eYFP\u2010treated controls. Our findings support a critical role for MCH\u2010expressing neurons in the LHA in learned overeating behavior.<\/jats:p>","DOI":"10.1111\/jne.70210","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:14:07Z","timestamp":1780614847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lateral hypothalamic melanin concentrating hormone\u2010expressing neurons both promote and are required for cue\u2010potentiated feeding"],"prefix":"10.1111","volume":"38","author":[{"given":"Lauren M.","family":"Raycraft","sequence":"first","affiliation":[{"name":"Department of Psychology Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxin","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Psychology Michigan State University  East Lansing Michigan 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