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NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes. Their malignant transformation is characterized by low mutational burden, suggesting that epigenetic mechanisms may be at play. Recent understanding of epigenetic events driving cancer cell plasticity and tumour initiation has led to advances in the diagnosis and prognosis of NETs. Here, we provide a brief overview of NETs, including their current diagnosis and management, and present recent progress in understanding the role of epigenetic regulation, highlighting how this may influence NET tumorigenesis and may be used in therapeutic applications. Finally, this literature review emphasizes the need to gather more data on these rare malignancies to improve patient outcome.<\/jats:p>","DOI":"10.1111\/jne.70211","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:48:56Z","timestamp":1780886936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment"],"prefix":"10.1111","volume":"38","author":[{"given":"Victoria","family":"Jacquot","sequence":"first","affiliation":[{"name":"Gastroenterology and Technologies for Health, Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052\u2010CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Gastroenterology and Technologies for Health, Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052\u2010CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walter","sequence":"additional","affiliation":[{"name":"Gastroenterology and Technologies for Health, Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052\u2010CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon1  Lyon France"},{"name":"Hospices Civils de Lyon, H\u00f4pital Edouard Herriot Service de Gastroent\u00e9rologie et d'Oncologie Digestive  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gibert","sequence":"additional","affiliation":[{"name":"Gastroenterology and Technologies for Health, Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052\u2010CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ouzounova","sequence":"additional","affiliation":[{"name":"Gastroenterology and Technologies for Health, Centre de Recherche en Canc\u00e9rologie de Lyon, INSERM U1052\u2010CNRS UMR5286, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard Lyon1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4351-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4518"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11276-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21063"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57305-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal2380"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","unstructured":"Epigenetic Therapies in Endocrine\u2010Related Cancers: Past Insights and Clinical Progress. 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