{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:02:43Z","timestamp":1784854963352,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011577","name":"Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hyperthyroidism is associated with cognitive impairment and neuropsychiatric symptoms, yet its effects on white matter architecture and neuromolecular organization remain poorly understood. We examined how hyperthyroidism alters white matter wiring architecture and the neuromodulatory systems underlying these disturbances. Diffusion MRI\u2010derived structural connectomes were analyzed in 30 patients with hyperthyroidism (HT) and 28 matched healthy controls (HC). Structural connections were classified into short\u2010, medium\u2010, and long\u2010range pathways, and global and nodal network topology was quantified using graph theoretical analysis. Molecular associations were examined using nine PET\u2010derived neurotransmitter receptor density maps through spatial correlation, multiple regression, and dominance analysis. Associations with thyroid hormone levels, clinical measures, and cognitive scores were evaluated using permutation\u2010based statistical testing. Neurotransmitter\u2010weighted network measures were computed by linking normative neurotransmitter density with graph theoretical metrics. Spatial autocorrelation was controlled using spin permutation testing, with results additionally corrected for multiple comparisons using false discovery rate (FDR) correction. Hyperthyroid patients exhibited significantly increased medium\u2010range (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.002) and long\u2010range connectivity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.02), reduced modularity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.009), and increased characteristic path length (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.032) as compared to controls, indicating disrupted segregation and efficiency. Nodal alterations were predominantly right\u2010lateralized, involving cortical, subcortical, and cerebellar regions. Clinically, BMI predicted modularity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.01), while free thyroxine levels predicted characteristic path length (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.04) and long\u2010range connectivity strength (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.03). The Nahor\u2013Benson score was associated with increased medium\u2010range connectivity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.02) and nodal degree (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.03) in right cerebellar lobule IV\u2013V. Neurotransmitter receptor distributions explained substantial variance in network topology (adjusted\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.45 in controls; 0.38 in hyperthyroidism), with dominant contributions from 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    (33%) and dopamine transporter (17%). Furthermore, 5\u2010HTT\u2010weighted within module degree z\u2010score predicted thyroid\u2010stimulating hormone (TSH) levels in hyperthyroidism (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.03), linking hormonal dysregulation to molecular connectomic reorganization. Our findings suggest that excess thyroid hormone drives right\u2010lateralized connectomic reorganization and increased metabolic demand, mediated by serotonergic and dopaminergic receptor architecture, linking endocrine dysfunction to large\u2010scale brain network vulnerability. These insights inform mechanistic models and biomarkers for clinical translation.\n                  <\/jats:p>","DOI":"10.1111\/jne.70235","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:36:33Z","timestamp":1784363793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Right\u2010lateralized maladaptive topological reorganization in hyperthyroidism"],"prefix":"10.1111","volume":"38","author":[{"given":"Priyanka","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Mathematics Rampurhat College  Rampurhat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Clinical Functional Imaging Group, Department of Nuclear Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO)  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Rana","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO)  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Saha","sequence":"additional","affiliation":[{"name":"School of Electronics Engineering Vellore Institute of Technology  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'souza","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO)  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Sekhri","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO)  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash","family":"Khushu","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO)  Delhi India"},{"name":"The University of Trans\u2010Disciplinary Health Sciences and Technology  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine and Allied Sciences (INMAS) Defence Research and Development Organisation (DRDO)  Delhi India"},{"name":"The University of Trans\u2010Disciplinary Health Sciences and Technology  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503770867174"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2015.tb00636.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19052"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000438"},{"key":"e_1_2_12_6_1","first-page":"83","article-title":"Hyperthyroidism in the elderly. 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