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We examined whether panic\u2010related respiratory and behavioural responses to respiratory challenges vary across reproductive stages. Female rats with regular estrous cycles (RC), representing reproductive cyclicity, and rats in periestropause (PE), a stage similar to perimenopause, were exposed to normoxia, hypoxia, and hypercapnia. Ventilation (V\u0307\n                    <jats:sub>E<\/jats:sub>\n                    ) and metabolism (V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    ) were measured during diestrus in RC and PE rats. Additionally, to measure levels of neuroinflammation, microglial reactivity in the Locus coeruleus (LC) in response to hypoxia\u2010induced panic\u2010like attacks was assessed. Under normoxia, there were no differences in V\u0307\n                    <jats:sub>E<\/jats:sub>\n                    or V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    between groups. Hypercapnia increased V\u0307\n                    <jats:sub>E<\/jats:sub>\n                    in both groups by elevating respiratory frequency (f\n                    <jats:sub>R<\/jats:sub>\n                    ) and tidal volume (V\n                    <jats:sub>T<\/jats:sub>\n                    ), without changing body temperature (Tb). Hypoxia also raised V\u0307\n                    <jats:sub>E<\/jats:sub>\n                    in both groups, primarily driven by increased f\n                    <jats:sub>R<\/jats:sub>\n                    , and hypoxia\u2010induced hypothermia occurred in RC and PE females. Both hypercapnia and hypoxia elevated the V\u0307\n                    <jats:sub>E<\/jats:sub>\n                    \/V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    ratio. Exposure to 7% O\n                    <jats:sub>2<\/jats:sub>\n                    heightened panic\u2010like behaviours in PE rats. Hypoxia increased LC microglial number, density, and mean soma size, while decreasing arborization area. PE rats also showed a higher microglial morphological index and a shorter nearest neighbour distance (NND). Jump frequency and freezing duration positively correlated with the morphological index and negatively with arborization area. These findings suggest that respiratory regulation remains intact, but behavioural and neuroimmune responses are amplified during the transition to estropause, heightening vulnerability to panic and anxiety\u2010related disorders in ageing females.\n                  <\/jats:p>","DOI":"10.1111\/jne.70254","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:14:26Z","timestamp":1788423266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periestropause enhances hypoxia\u2010induced panic and microglial remodelling without altering respiratory control"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-4332","authenticated-orcid":false,"given":"Angela Cristina","family":"Nicola","sequence":"first","affiliation":[{"name":"Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences S\u00e3o Paulo State 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