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Whether such symmetry\u2010to\u2010asymmetry conversion can be driven at the systems level by neurohormonal regulators remains unclear. Here we tested whether a spatially symmetric neuroendocrine challenge\u2014water deprivation (WD)\u2014can elicit a directional left\u2013right physiological response in rats using hindlimb postural asymmetry (HL\u2010PA), a binary readout that quantifies left\u2010 versus right\u2010sided hindlimb flexion. Twenty\u2010four hours of WD induced robust HL\u2010PA with right hindlimb flexion, revealed under anesthesia. The asymmetry persisted after complete thoracic spinal cord transection, suggesting that humoral signaling, rather than descending neural commands, maintains the postural bias. Dehydration activated the hypothalamic arginine vasopressin (AVP) system. Furthermore, a V1B antagonist (SSR\u2010149415) and a V1A\/V2 antagonist (conivaptan) abolished and partially attenuated WD\u2010induced HL\u2010PA, respectively, supporting an AVP\u2010dependent mechanism that likely operates at least two anatomical sites. AVP signaling may involve pituitary V1B\u2010dependent endocrine output and spinal V1A actions; consistent with the latter, expression of AVP V1A receptors is right\u2010biased in lumbar spinal cord. Together, these findings identify WD as a symmetric systemic challenge capable of unmasking a directional peripheral bias and implicate vasopressin signaling in left\u2013right physiological regulation. More broadly, they suggest that symmetric homeostatic challenges engage neuroendocrine mechanisms that shift the balance between left\u2010 and right\u2010sided physiological functions.<\/jats:p>","DOI":"10.1111\/jne.70257","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:35:56Z","timestamp":1788755756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A symmetric systemic challenge elicits a right\u2010biased response mediated by vasopressin signaling"],"prefix":"10.1111","volume":"38","author":[{"given":"Hiroyuki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biosciences Uppsala University  Uppsala Sweden"},{"name":"Department of Molecular Medicine University of Southern Denmark  Odense M 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