{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:02:12Z","timestamp":1790643732233,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    During pregnancy, thermoregulation is tightly controlled to protect the foetus from harmful elevated temperatures. Stress\u2010induced hyperthermia is a component of the stress response that increases alertness to a perceived threat. Previous literature has shown that like other aspects of the stress response, stress\u2010induced hyperthermia is attenuated in late pregnancy. We sought to investigate how stress\u2010induced hyperthermia is attenuated in pregnancy of mice. The lactogenic hormones, prolactin and placental lactogen, have been previously shown to act through the prolactin receptor (Prlr) to keep maternal temperature in pregnancy low to ensure successful reproductive outcomes. We hypothesised that Prlr signalling in the brain would attenuate stress\u2010induced hyperthermia during pregnancy. To investigate this, we specifically knocked out Prlr from glutamatergic (Vglut2) neurons in mice (\n                    <jats:italic>Prlr<\/jats:italic>\n                    <jats:sup>lox\/lox<\/jats:sup>\n                    \/\n                    <jats:italic>Vglut2<\/jats:italic>\n                    <jats:sup>Cre<\/jats:sup>\n                    ). These neurons have been implicated in maternal adaptations and in stress\u2010induced hyperthermia. Using radiotelemetry to record core temperature (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>core<\/jats:sub>\n                    ) and activity levels, non\u2010pregnant and pregnant mice were handled daily by scruffing the skin on the back of the neck to elicit a stress\u2010induced hyperthermic response. In pregnant control mice (\n                    <jats:italic>Prlr<\/jats:italic>\n                    <jats:sup>lox\/lox<\/jats:sup>\n                    ), stress\u2010induced hyperthermia became attenuated from day 12 of pregnancy. This was not due to habituation to the stressor, as non\u2010pregnant mice did not show any attenuation of the stress\u2010induced\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>core<\/jats:sub>\n                    response following repeated handling for up to 20\u2009days. In the\n                    <jats:italic>Prlr<\/jats:italic>\n                    <jats:sup>lox\/lox<\/jats:sup>\n                    \/\n                    <jats:italic>Vglut2<\/jats:italic>\n                    <jats:sup>Cre<\/jats:sup>\n                    mice, the pregnancy\u2010induced attenuation of stress\u2010induced\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>core<\/jats:sub>\n                    was markedly delayed, only appearing at day 14 of pregnancy. The changes were specific to the temperature response to stress, as both genotypes displayed similar levels of stress\u2010induced activity following handling. Together, these data demonstrate that stress\u2010induced hyperthermia is attenuated during pregnancy in mice and that this effect is at least partially mediated by Prlr signalling in glutamate neurons. However, as the stress\u2010induced\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>core<\/jats:sub>\n                    response of the knockout mice was eventually attenuated in late pregnancy (gestation day 15\u201317), comparable to controls, other factors may also be involved.\n                  <\/jats:p>","DOI":"10.1111\/jne.70261","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:15:17Z","timestamp":1790640917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolactin receptor signalling contributes to the attenuation of stress\u2010induced hyperthermia during pregnancy"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8776-3167","authenticated-orcid":false,"given":"Andrew M.","family":"Stewart","sequence":"first","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy, Faculty of Biomedical Sciences University of Otago  Dunedin New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-2559","authenticated-orcid":false,"given":"David R.","family":"Grattan","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy, Faculty of Biomedical Sciences University of Otago  Dunedin New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-8319","authenticated-orcid":false,"given":"Teodora R.","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy, Faculty of Biomedical Sciences University of Otago  Dunedin New Zealand"},{"name":"Maurice Wilkins Centre for Molecular 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