{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:58:59Z","timestamp":1790319539508,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolactinomas in the transition age present unique challenges; treatment strategies and long\u2010term outcomes in this population remain incompletely characterised. This is a multicentre, retrospective study of 110 consecutive patients (33 males) with prolactinomas, aged 15\u201325\u2009years, across five Italian referral centres (2010\u20132025). Clinical, hormonal, radiological, and treatment\u2010related parameters were assessed at diagnosis and at follow\u2010up. At diagnosis, the median age was 20\u2009years; median prolactin 177\u2009ng\/mL [49\u20136646]; 55% of patients had micro\u2010tumours. Male patients presented with larger tumours, higher prolactin levels, and greater invasiveness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001 for all comparisons). Cabergoline was first\u2010line therapy in 95%, achieving prolactin normalisation in 75% and significant tumour shrinkage (\u226550% volume and\/or diameter reduction) in 66% of patients. Partial resistance (biochemical and\/or radiological) occurred in 40% of patients. Treatment discontinuation occurred in 48% of cases; 61% of patients discontinuing cabergoline after prolonged normalisation experienced recurrence, which was predicted by younger age at diagnosis (OR 0.67\/year,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.040) and shorter treatment duration (OR 0.95\/month,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.050), the latter showed 93% sensitivity for recurrence at 45.5\u2009months. Adverse events occurred in 12%, leading to treatment discontinuation in 6%. Surgery was required in 17%, achieving long\u2010term remission in 31%, while 21% of surgical cases required radiotherapy. At last follow\u2010up (median 72\u2009months), 73% remained on cabergoline while 25% achieved complete radiological resolution. Transition\u2010age prolactinomas demonstrate high cabergoline resistance rates and frequent recurrence after discontinuation. Treatment duration \u226545.5\u2009months before withdrawal may reduce recurrence risk. Surgical remission is achievable, especially in non\u2010invasive tumours, although multimodal therapy is often required for disease control.\n                  <\/jats:p>","DOI":"10.1111\/jne.70275","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:03:39Z","timestamp":1790316219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolactinomas in the transition from adolescence to young adulthood: A multicentre, retrospective study from the\n                    <scp>TALENT<\/scp>\n                    group"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-1761","authenticated-orcid":false,"given":"Dario","family":"De Alcubierre","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine Sapienza University  Rome Italy"},{"name":"Neuroendocrinology IRCCS Neuromed Institute  Pozzilli 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Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-9146","authenticated-orcid":false,"given":"Giulia","family":"Puliani","sequence":"additional","affiliation":[{"name":"Oncological Endocrinology Unit IRCCS Regina Elena National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-9328","authenticated-orcid":false,"given":"Rosa","family":"Pirchio","sequence":"additional","affiliation":[{"name":"Dipartimento Di Medicina Clinica E Chirurgia, Sezione Di Endocrinologia, Diabetologia, Andrologia e Nutrizione Universit\u00e0 Federico II Di Napoli  Naples Italy"},{"name":"Rare Endocrine Diseases Endo\u2010ERN Unit Azienda Ospedaliera Universitaria \u201cFederico II\u201d  Naples 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