{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:52:34Z","timestamp":1791157954954,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH108663\u201003"],"award-info":[{"award-number":["R01MH108663\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32NS041228\u201022"],"award-info":[{"award-number":["T32NS041228\u201022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["3R01DA050454\u201004S1"],"award-info":[{"award-number":["3R01DA050454\u201004S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001863"],"award-info":[{"award-number":["UL1 TR001863"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1 TR001864"],"award-info":[{"award-number":["TL1 TR001864"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004823","name":"Connecticut State Department of Mental Health and Addiction Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Social withdrawal during cocaine abstinence is a significant predictor of relapse, yet the neuroendocrine mechanisms underlying this vulnerability remain poorly understood, particularly in females. Estradiol, a potent neuromodulator of mesocorticolimbic circuitry, regulates dopamine\u2010dependent processes that encode social motivation. L\u2010type calcium channels (LTCCs) similarly regulate neuronal excitability and plasticity in corticolimbic regions implicated in addiction and affective regulation, and estradiol interacts with LTCC signaling through both membrane\u2010initiated and transcriptional mechanisms. However, whether estradiol and LTCCs functionally converge to regulate social behavior during cocaine abstinence is unknown. Here, we used a preclinical behavioral pharmacology approach to examine this interaction in female Sprague\u2013Dawley rats. Ovariectomized (OVX) rats with or without 17\u03b2\u2010estradiol replacement underwent jugular catheterization and self\u2010administered cocaine (0.5\u2009mg\/kg\/inf, FR1) or saline for 10\u2009days, followed by 17\u2009days of forced abstinence. Social preference was assessed using a three\u2010chamber social interaction test, with systemic isradipine (1.2\u2009mg\/kg, i.p.) administered 15\u2009min prior to testing. Cocaine abstinence significantly reduced social preference in intact females. LTCC blockade with isradipine restored social preference, but this effect was dependent on ovarian hormone status: isradipine normalized social behavior in sham\u2010operated and OVX\u2009+\u2009E2 rats but not in OVX rats lacking estradiol. Multiple linear regression confirmed that ovarian hormone status and isradipine treatment, but not total cocaine intake, significantly predicted social preference, with a robust hormone\u2009\u00d7\u2009isradipine interaction explaining 44.6% of behavioral variance. These findings demonstrate that estradiol does not simply protect against abstinence\u2010related social deficits but rather biases neural signaling such that social behavior becomes sensitive to LTCC\u2010dependent mechanisms. This work identifies a functional estradiol\u2013LTCC interaction regulating social motivation during cocaine abstinence and highlights the importance of hormonal state in shaping sex\u2010specific addiction vulnerability.<\/jats:p>","DOI":"10.1111\/jne.70280","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:30:31Z","timestamp":1791156631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estradiol regulates L\u2010type calcium channel\u2010dependent social behavior deficits during cocaine abstinence in female rats"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-9643","authenticated-orcid":false,"given":"Violet M.","family":"Kimble","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"},{"name":"Interdepartmental Neuroscience Program Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-6937","authenticated-orcid":false,"given":"Mary","family":"Zanda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayde","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-0907","authenticated-orcid":false,"given":"Clare","family":"Flannery","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Internal Medicine, Section of Endocrinology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5831-8595","authenticated-orcid":false,"given":"Jane R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-5466","authenticated-orcid":false,"given":"Anjali","family":"Rajadhyaksha","sequence":"additional","affiliation":[{"name":"Center for Substance Abuse Research and Department of Neural Sciences Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9321-6067","authenticated-orcid":false,"given":"Nii A.","family":"Addy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"},{"name":"Interdepartmental Neuroscience Program Yale University  New Haven Connecticut USA"},{"name":"Department of Cellular and Molecular Physiology Yale School of Medicine  New Haven Connecticut USA"},{"name":"Wu Tsai Institute Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yfrne.2007.07.003","article-title":"Sex differences in drug abuse","volume":"29","author":"Becker JB","year":"2008","journal-title":"Front Neuroendocrinol"},{"issue":"9","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrn.2016.67","article-title":"Time to connect: bringing social context into addiction neuroscience","volume":"17","author":"Heilig M","year":"2016","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/wps.21073","article-title":"Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention","volume":"22","author":"Volkow ND","year":"2023","journal-title":"World Psychiatry"},{"issue":"4","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.31887\/DCNS.2016.18.4\/jbecker","article-title":"Sex differences in addiction","volume":"18","author":"Becker JB","year":"2016","journal-title":"Dialogues Clin Neurosci"},{"issue":"2","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0193-953X(05)70074-5","article-title":"Gender differences in substance use disorders","volume":"22","author":"Brady KT","year":"1999","journal-title":"Psychiatr Clin North Am"},{"issue":"9","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa129","article-title":"Sexual differentiation and substance use: a mini\u2010review","volume":"161","author":"Harp SJ","year":"2020","journal-title":"Endocrinology"},{"issue":"7","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1073\/pnas.1324287111","article-title":"Social cognition in cocaine addiction","volume":"111","author":"Verdejo\u2010Garcia A","year":"2014","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13877","article-title":"Dopaminergic dynamics underlying sex\u2010specific cocaine reward","volume":"8","author":"Calipari ES","year":"2017","journal-title":"Nat Commun"},{"issue":"4","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1006\/hbeh.2002.1837","article-title":"Estrogen receptor \u03b1 influences socially motivated behaviors","volume":"42","author":"Imwalle DB","year":"2002","journal-title":"Horm Behav"},{"issue":"2","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/1871524914666141226103135","article-title":"Estradiol, dopamine and motivation","volume":"14","author":"Yoest KE","year":"2014","journal-title":"Cent Nerv Syst Agents Med Chem"},{"issue":"9","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1111\/ejn.15179","article-title":"Deconstructing the contribution of sensory cues in social approach","volume":"53","author":"Contestabile A","year":"2021","journal-title":"Eur J Neurosci"},{"issue":"7","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.cell.2014.05.017","article-title":"Natural neural projection dynamics underlying social behavior","volume":"157","author":"Gunaydin LA","year":"2014","journal-title":"Cell"},{"issue":"1","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28512-4","article-title":"Superior colliculus to VTA pathway controls orienting response and influences social interaction in mice","volume":"13","author":"Soli\u00e9 C","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41593-021-00972-9","article-title":"VTA dopamine neuron activity encodes social interaction and promotes reinforcement learning through social prediction error","volume":"25","author":"Soli\u00e9 C","year":"2022","journal-title":"Nat Neurosci"},{"issue":"5","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/sj.npp.1300656","article-title":"Decreased motivation following cocaine self\u2010administration under extended access conditions: effects of sex and ovarian hormones","volume":"30","author":"Lynch WJ","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"50","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2255-10.2010","article-title":"Molecular switch from L\u2010type Ca\n                     v\n                  1.3 to Ca\n                     v\n                  1.2 Ca2+ channel signaling underlies long\u2010term psychostimulant\u2010induced behavioral and molecular plasticity","volume":"30","author":"Giordano TP","year":"2010","journal-title":"J Neurosci"},{"issue":"3","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s13311-017-0532-0","article-title":"From gene to behavior: L\u2010type calcium channel mechanisms underlying neuropsychiatric symptoms","volume":"14","author":"Kabir ZD","year":"2017","journal-title":"Neurotherapeutics"},{"issue":"5","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/jn.00757.2013","article-title":"Cav1.2 and Cav1.3 L\u2010type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area","volume":"112","author":"Liu Y","year":"2014","journal-title":"J Neurophysiol"},{"issue":"39","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"15148","DOI":"10.1073\/pnas.0802379105","article-title":"Estrogens directly potentiate neuronal L\u2010type Ca2+ channels","volume":"105","author":"Sarkar SN","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"45","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"16056","DOI":"10.1523\/JNEUROSCI.4097-11.2011","article-title":"Rapid estrogen signaling in the brain: implications for the fine\u2010tuning of neuronal circuitry","volume":"31","author":"Srivastava DP","year":"2011","journal-title":"J Neurosci"},{"issue":"2","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/hbeh.1998.1466","article-title":"Estrogen\u2010mediated structural and functional synaptic plasticity in the female rat hippocampus","volume":"34","author":"Woolley CS","year":"1998","journal-title":"Horm Behav"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115613","article-title":"L\u2010type calcium channel blockade attenuates cue\u2010induced cocaine\u2010seeking in female rats","volume":"490","author":"Kimble VM","year":"2025","journal-title":"Behav Brain Res"},{"issue":"12","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1038\/s41386-018-0080-2","article-title":"The L\u2010type calcium channel blocker, isradipine, attenuates cue\u2010induced cocaine\u2010seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway","volume":"43","author":"Addy NA","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroscience.2025.01.003","article-title":"L\u2010type calcium channel blockade attenuates the anxiogenic\u2010like effects of cocaine abstinence in female and male rats","volume":"568","author":"Nunes EJ","year":"2025","journal-title":"Neuroscience"},{"issue":"1","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2042-6410-3-14","article-title":"Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis","volume":"3","author":"Becker JB","year":"2012","journal-title":"Biol Sex Differ"},{"issue":"5","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tips.2004.03.011","article-title":"Sex and estrogen influence drug abuse","volume":"25","author":"Carroll ME","year":"2004","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.neuron.2004.10.013","article-title":"State\u2010dependent calcium signaling in dendritic spines of striatal medium spiny neurons","volume":"44","author":"Carter AG","year":"2004","journal-title":"Neuron"},{"issue":"3","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0896-6273(00)80798-9","article-title":"Beyond the dopamine receptor: the DARPP\u201032\/protein phosphatase\u20101 cascade","volume":"23","author":"Greengard P","year":"1999","journal-title":"Neuron"},{"issue":"5","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/1073858405278236","article-title":"Psychostimulants, L\u2010type calcium channels, kinases, and phosphatases","volume":"11","author":"Rajadhyaksha AM","year":"2005","journal-title":"Neuroscientist"},{"issue":"1","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuropharm.2011.04.002","article-title":"Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens","volume":"61","author":"Wissman AM","year":"2011","journal-title":"Neuropharmacology"},{"issue":"3","key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yfrne.2009.04.011","article-title":"Membrane estradiol signaling in the brain","volume":"30","author":"Micevych P","year":"2009","journal-title":"Front Neuroendocrinol"},{"issue":"40","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1523\/JNEUROSCI.3264-10.2010","article-title":"Estrogen receptor \u00df activity modulates synaptic signaling and structure","volume":"30","author":"Srivastava DP","year":"2010","journal-title":"J Neurosci"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yhbeh.2015.06.010","article-title":"Estrogen receptors in the central nervous system and their implication for dopamine\u2010dependent cognition in females","volume":"74","author":"Almey A","year":"2015","journal-title":"Horm Behav"},{"issue":"11","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/cne.25320","article-title":"Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: evidence for localization to catecholaminergic and GABAergic neurons","volume":"530","author":"Almey A","year":"2022","journal-title":"J Comp Neurol"},{"issue":"20","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1523\/JNEUROSCI.1427-05.2005","article-title":"Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element\u2010binding protein","volume":"25","author":"Boulware MI","year":"2005","journal-title":"J Neurosci"},{"issue":"1","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2008.04.005","article-title":"Caveolin proteins and estrogen signaling in the brain","volume":"290","author":"Luoma JI","year":"2008","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1074\/jbc.M205692200","article-title":"Proximal events in signaling by plasma membrane estrogen receptors","volume":"278","author":"Razandi M","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-3565(25)10267-X","article-title":"Chronic cocaine disruption of estrous cyclicity in the rat: dose\u2010dependent effects","volume":"264","author":"King TS","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/sj.npp.1300511","article-title":"The effects of cocaine on gonadal steroid hormones and LH in male and female rhesus monkeys","volume":"29","author":"Mello NK","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3565(24)29539-2","article-title":"Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo\u2010pituitary\u2010adrenal axis by cocaine","volume":"297","author":"Walker QD","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pnpbp.2014.05.009","article-title":"Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders","volume":"54","author":"Borrow AP","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.yhbeh.2015.05.023","article-title":"Estrogen involvement in social behavior in rodents: rapid and long\u2010term actions","volume":"74","author":"Ervin KSJ","year":"2015","journal-title":"Horm Behav"},{"issue":"3","key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-9343(88)90192-1","article-title":"Pharmacokinetics and pharmacodynamics of isradipine (PN 200\u2010110) in young and elderly patients","volume":"84","author":"Chellingsworth MC","year":"1988","journal-title":"Am J Med"},{"issue":"4","key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF00543970","article-title":"Pharmacokinetics of PN 200\u2010110 (isradipine), a new calcium antagonist, after oral administration in man","volume":"32","author":"Tse FLS","year":"1987","journal-title":"Eur J Clin Pharmacol"},{"issue":"9","key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.2042-7158.1989.tb06554.x","article-title":"Bioavailability of isradipine in young and old rats: effect of mode of administration","volume":"41","author":"Tse FLS","year":"1989","journal-title":"J Pharm Pharmacol"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.70280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.70280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.70280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:30:37Z","timestamp":1791156637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.70280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jne.70280"],"URL":"https:\/\/doi.org\/10.1111\/jne.70280","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70280"}}