{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:52:56Z","timestamp":1791849176540,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271\u2010TRR 205"],"award-info":[{"award-number":["314061271\u2010TRR 205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC\u20101665\u2013515637292"],"award-info":[{"award-number":["CRC\u20101665\u2013515637292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["325768017"],"award-info":[{"award-number":["325768017"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["507872050"],"award-info":[{"award-number":["507872050"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["Synergy award 101166968 (\u201cMicroClock\u201d)"],"award-info":[{"award-number":["Synergy award 101166968 (\u201cMicroClock\u201d)"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cushing's syndrome is characterised by chronic glucocorticoid excess that abolishes the physiological circadian cortisol rhythm. We investigated whether this circadian disruption alters chronotype. In a single\u2010centre case\u2013control study, chronotype was assessed using the Munich ChronoType Questionnaire (MCTQ;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009119) and wrist actigraphy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200939) in patients with active Cushing's syndrome, patients in biochemical remission, and healthy controls. The primary outcome was mid\u2010sleep on free days corrected for sleep debt (MSFsc). Multivariable analysis was performed to identify independent predictors of chronotype. Agreement between methods was assessed by Bland\u2013Altman analysis. Patients with active Cushing's syndrome had a significantly earlier chronotype than patients in remission and controls (MSFsc by MCTQ: 2.38\u2009h [IQR 1.22; 3.41] vs. 3.29\u2009h [IQR 2.65; 4.32] vs. 3.73\u2009h [IQR 3.16; 4.08];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.007 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0003, respectively; actigraphy: 3.15\u2009\u00b1\u20090.90\u2009h vs. 4.03\u2009\u00b1\u20090.96\u2009h vs. 4.46\u2009\u00b1\u20090.75\u2009h;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.039 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001, respectively). Chronotype did not differ significantly between patients in remission and controls. In a multivariable quantile regression model, active Cushing's syndrome was an independent predictor of chronotype (1.32\u2009h earlier than controls;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.049), while age, BMI, psychiatric symptoms and sleep disturbance had no significant influence. Actigraphy confirmed earlier sleep offset and acrophase in active Cushing's syndrome. MCTQ and actigraphy were significantly correlated (Pearson\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.619,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0003,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929); agreement analysis revealed no systematic bias, but a significant proportional bias, reflecting wider dispersion of MCTQ\u2010derived values. Patients with active Cushing's syndrome have an earlier chronotype than patients in remission and healthy controls, as determined by both subjective and objective methods. Chronotype assessment, particularly with the MCTQ, may complement biochemical monitoring.\n                  <\/jats:p>","DOI":"10.1111\/jne.70286","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:25:01Z","timestamp":1791505501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cushing's syndrome is associated with an advanced chronotype"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-9929","authenticated-orcid":false,"given":"Hanna","family":"Nowotny","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Albani","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Mazari","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5233-3661","authenticated-orcid":false,"given":"Stephanie","family":"Zopp","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-2360","authenticated-orcid":false,"given":"Martha","family":"Merrow","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-6069","authenticated-orcid":false,"given":"Nicole","family":"Reisch","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-0602","authenticated-orcid":false,"given":"Luis Gustavo","family":"Perez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-4374","authenticated-orcid":false,"given":"Marily","family":"Theodoropoulou","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Medizin Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich 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