{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:49:59Z","timestamp":1762177799766,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuropsychology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n Background<\/jats:title>\n \n Earlier research has found cross\u2010sectional attentional control deficits in manifest Huntington's disease (\n HD<\/jats:styled-content>\n ) using neuropsychological testing combined with simultaneous P300 registration. In the current pilot\u2010study, we investigate attentional control in pre\u2010manifest and manifest\n HD<\/jats:styled-content>\n over a 3\u2010year follow\u2010up period.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Five manifest\n HD<\/jats:styled-content>\n (\n MHD<\/jats:styled-content>\n ), 9 pre\u2010manifest\n HD<\/jats:styled-content>\n (\n PMHD<\/jats:styled-content>\n ), and 12 control subjects were included. Sustained Attention to Response task (\n SART<\/jats:styled-content>\n ) and P300 registration resulted in number of errors, reaction time (\n RT<\/jats:styled-content>\n ), and P300 amplitude and latency.\n RT<\/jats:styled-content>\n change patterns surrounding No\u2010go trials were also investigated. Within\u2010subject differences were tested using paired\u2010samples\n t\u2010<\/jats:italic>\n tests and between\u2010group results with\n ANCOVA<\/jats:styled-content>\n on delta scores (follow\u2010up \u2013 baseline scores).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Manifest HD made more errors and were slower than controls and\n PMHD<\/jats:styled-content>\n . Longitudinally,\n MHD<\/jats:styled-content>\n showed an overall\n RT<\/jats:styled-content>\n increase and a specific slowing on trials preceding a correct No\u2010go trial (within\u2010group effects). The latter was also seen in\n PMHD<\/jats:styled-content>\n . P300 latency prolongation was found for controls on No\u2010go and for\n MHD<\/jats:styled-content>\n on Go trials. On specific trials surrounding both correct and incorrect No\u2010go trials,\n MHD<\/jats:styled-content>\n became significantly slower over time than controls and\n PMHD<\/jats:styled-content>\n (between\u2010group effects).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Over 3\u2010years,\n MHD<\/jats:styled-content>\n subjects became slower on the\n SART<\/jats:styled-content>\n and showed a prolongation of P300 latency on specific\n SART<\/jats:styled-content>\n trials. Specific slowing of performance over time was also seen in\n PMHD<\/jats:styled-content>\n , suggestive of compensatory mechanisms in this group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jnp.12031","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T01:00:47Z","timestamp":1382576447000},"page":"10-20","source":"Crossref","is-referenced-by-count":14,"title":["Longitudinal pilot\u2010study of Sustained Attention to Response Task and P300 in manifest and pre\u2010manifest Huntington's disease"],"prefix":"10.1111","volume":"9","author":[{"given":"Ellen P.","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve M.","family":"Dumas","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik W.","family":"van Zwet","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"van der Hiele","sequence":"additional","affiliation":[{"name":"Clinical Neuropsychology Unit Institute of Psychology Leiden University Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline K.","family":"Jurgens","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Bronovo Hospital The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huub A. 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