{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:02:28Z","timestamp":1791255748132,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"MRC-ESRC"},{"name":"MRC","award":["MR\/J004146\/1"],"award-info":[{"award-number":["MR\/J004146\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuropsychology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>\n                    Executive control is impaired from the early stages of\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    lzheimer's Disease (\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    ) and this produces deregulated semantic cognition (Corbett, Jefferies, Burns, &amp; Lambon Ralph, ; Perry, Watson, &amp; Hodges, ). While control deficits should affect semantic retrieval across all modalities, previous studies have typically focused on verbal semantic tasks. Even when non\u2010verbal semantic tasks have been used, these have typically employed simple picture\u2010matching tasks, which may be influenced by abnormalities in covert naming. Therefore, in the present study, we examined 10 patients with\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    on a battery of object\u2010use tasks, in order to advance our understanding of the origins of non\u2010verbal semantic deficits in this population. The\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    patients\u2019 deficits were contrasted with previously published performance on the same tasks within two additional groups of patients, displaying either semantic degradation (semantic dementia) or deregulation of semantic retrieval (semantic aphasia; Corbett, Jefferies, Ehsan, &amp; Lambon Ralph, ). While overall accuracy was comparable to the scores in both other groups, the\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    patients\u2019 object\u2010use impairment most closely resembled that observed in\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    ; they exhibited poorer performance on comprehension tasks that placed strong demands on executive control. A similar pattern was observed in the expressive domain: the\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    groups were relatively good at straightforward object use compared to executively demanding, mechanical puzzles. Error types also differed: while all patients omitted essential actions, the\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    groups\u2019 demonstrations also featured unrelated intrusions. An association between\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    patients\u2019 object use and their scores on standard executive measures suggested that control deficits contributed to their non\u2010verbal semantic deficits. Moreover, in a task specifically designed to manipulate executive demand, patients with\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    (and\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    ) exhibited difficulty in thinking flexibly about the non\u2010canonical uses of everyday objects, especially when distracted by semantically related objects. This study provides converging evidence for the notion that a failure of regulatory control contributes to multimodal semantic impairment in\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    and uniquely demonstrates this pattern for the highly non\u2010verbal domain of object use.\n                  <\/jats:p>","DOI":"10.1111\/jnp.12047","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T06:36:49Z","timestamp":1402295809000},"page":"219-241","source":"Crossref","is-referenced-by-count":22,"title":["Deregulated semantic cognition contributes to object\u2010use deficits in\n                    <scp>A<\/scp>\n                    lzheimer's disease: A comparison with semantic aphasia and semantic dementia"],"prefix":"10.1111","volume":"9","author":[{"given":"Faye","family":"Corbett","sequence":"first","affiliation":[{"name":"Neuroscience and Aphasia Research Unit (NARU) School of Psychological Sciences University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Department of Psychology University of York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Burns","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Human Sciences Institute of Brain Behaviour and Mental Health University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Lambon Ralph","sequence":"additional","affiliation":[{"name":"Neuroscience and Aphasia Research Unit (NARU) School of Psychological Sciences University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2007.02.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.04.022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1991.3.2.166"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00034-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.2.3.236"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.15.2.155"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2006.05.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.2.397"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643299208252064"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290342000113"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/902451"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp146"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.05.020"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2010.21539"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0521-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700666079"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.216"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2004.08.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.20.1.1.1484"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092534"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09658219508253161"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(94)00127-B"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.6.1783"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(92)90104-T"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.12.036"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2011.21614"},{"key":"e_1_2_6_29_1","volume-title":"Pyramid and palm trees: A test of semantic access from pictures and words","author":"Howard D.","year":"1992"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl153"},{"key":"e_1_2_6_31_1","first-page":"61","article-title":"Generalization and differentiation in semantic memory \u2010 Insights from semantic dementia","volume":"1124","author":"Lambon Ralph M. 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