{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:34:08Z","timestamp":1779341648471,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Miguel Servet Grant","award":["CP2\/00023"],"award-info":[{"award-number":["CP2\/00023"]}]},{"name":"Fondo Europeo de Desarrollo Regional, \u201cUna Manera de Hacer Europa\u201d","award":["FIS PI11\/01071"],"award-info":[{"award-number":["FIS PI11\/01071"]}]},{"name":"Ministerio de Econom\u00eda y Competitividad (Spanish Government)","award":["PSI2012-39149"],"award-info":[{"award-number":["PSI2012-39149"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuropsychology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Background<\/jats:title>\n \n Individuals with preclinical\n A<\/jats:styled-content>\n lzheimer's disease (\n P<\/jats:styled-content>\n re\u2010\n AD<\/jats:styled-content>\n ) present nonimpaired cognition, as measured by standard neuropsychological tests. However, detecting subtle difficulties in cognitive functions may be necessary for an early diagnosis and intervention.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n A new computer\u2010based visuomotor coordination task (\n VMC<\/jats:styled-content>\n ) was developed to investigate the possible presence of early visuomotor difficulties in\n P<\/jats:styled-content>\n re\u2010\n AD<\/jats:styled-content>\n individuals. Associations between\n VMC<\/jats:styled-content>\n task performance and\n AD<\/jats:styled-content>\n biomarkers were studied. The influence of\n A<\/jats:styled-content>\n po\n E<\/jats:styled-content>\n status on participants\u2019 performance was addressed, as well as the relationship between performance and subjective cognitive decline (\n SCD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixty\u2010six cognitively normal (\n CN<\/jats:styled-content>\n ) elders (19\n P<\/jats:styled-content>\n re\u2010\n AD<\/jats:styled-content>\n and 47 control participants [\n CTR<\/jats:styled-content>\n ]) and 15 patients with\n AD<\/jats:styled-content>\n performed the\n VMC<\/jats:styled-content>\n task, which consisted in executing visually guided goal\u2010directed movements that required the coordination of the visual and motor systems. All participants underwent\n A<\/jats:styled-content>\n po\n E<\/jats:styled-content>\n analysis and lumbar puncture.\n CN<\/jats:styled-content>\n participants also completed an extensive standard neuropsychological battery.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Despite presenting normal cognition in standard tests,\n P<\/jats:styled-content>\n re\u2010\n AD<\/jats:styled-content>\n participants exhibited higher response times (\n RT<\/jats:styled-content>\n s) to complete the\n VMC<\/jats:styled-content>\n task than\n CTR<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u00a0<\u00a0.01). Besides, patients with\n AD<\/jats:styled-content>\n showed higher\n RT<\/jats:styled-content>\n s than\n CTR<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u00a0<\u00a0.001) and Pre\u2010\n AD<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u00a0<\u00a0.05), and more errors than\n CTR<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u00a0<\u00a0.005).\n RT<\/jats:styled-content>\n s in\n A<\/jats:styled-content>\n po\n E<\/jats:styled-content>\n 4 carriers were higher than that observed in\n A<\/jats:styled-content>\n po\n E<\/jats:styled-content>\n 4 noncarriers (\n p<\/jats:italic>\n \u00a0<\u00a0.01). In\n CN<\/jats:styled-content>\n individuals,\n RT<\/jats:styled-content>\n s were related to amyloid \u03b2\u2010protein 42 (\n AB<\/jats:styled-content>\n 42) biomarker (\n p<\/jats:italic>\n \u00a0<\u00a0.01) and informant\u2010rated\n SCD<\/jats:styled-content>\n (\n p<\/jats:italic>\n \u00a0<\u00a0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The\n VMC<\/jats:styled-content>\n task is able to discriminate\n P<\/jats:styled-content>\n re\u2010\n AD<\/jats:styled-content>\n from\n CTR<\/jats:styled-content>\n individuals. Moreover,\n VMC<\/jats:styled-content>\n results are associated with\n AB<\/jats:styled-content>\n 42 levels in\n CN<\/jats:styled-content>\n individuals, suggesting that visuomotor dysfunction may be a sensitive marker of\n P<\/jats:styled-content>\n re\u2010\n AD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jnp.12079","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T10:10:39Z","timestamp":1436868639000},"page":"56-73","source":"Crossref","is-referenced-by-count":17,"title":["Subtle visuomotor difficulties in preclinical\n A<\/scp>\n lzheimer's disease"],"prefix":"10.1111","volume":"11","author":[{"given":"Maria A.","family":"Mollica","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Neurology Service Hospital Cl\u00ednic Barcelona 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