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Indeed, their atrophy distinctively disrupts both domains, as observed in patients with Huntington's disease (\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    ) and Parkinson's disease, even during early disease stages. However, frontostriatal degeneration in these conditions may begin up to 15\u00a0years before the onset of clinical symptoms, opening avenues for pre\u2010clinical detection via sensitive tasks. Such a mission is particularly critical in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    , given that patients\u2019 children have 50% chances of inheriting the disease. Against this background, we assessed whether deficits in the above\u2010mentioned domains emerge in subjects at risk to develop\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    . We administered tasks tapping action semantics, object semantics, and two forms of syntactic processing to 18 patients with\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    , 19 asymptomatic first\u2010degree relatives, and sociodemographically matched controls for each group. The patients evinced significant deficits in all tasks, but only those in the two target domains were independent of overall cognitive state. More crucially, relative to controls, the asymptomatic relatives were selectively impaired in action semantics and in the more complex syntactic task, with both patterns emerging irrespective of the subjects\u2019 overall cognitive state. Our findings highlight the relevance of these dysfunctions as potential prodromal biomarkers of\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    . Moreover, they offer theoretical insights into the differential contributions of frontostriatal hubs to both domains while paving the way for innovations in diagnostic procedures.\n                  <\/jats:p>","DOI":"10.1111\/jnp.12120","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T02:37:08Z","timestamp":1489199828000},"page":"389-408","source":"Crossref","is-referenced-by-count":22,"title":["Action\u2010semantic and syntactic deficits in subjects at risk for Huntington's disease"],"prefix":"10.1111","volume":"12","author":[{"given":"Adolfo M.","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Psychology and Neuroscience (LPEN) Institute of Cognitive and Translational Neuroscience (INCYT) INECO Foundation Favaloro University Buenos Aires Argentina"},{"name":"National Scientific and Technical Research Council (CONICET) Buenos Aires Argentina"},{"name":"Faculty of Education National University of Cuyo 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