{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:53:15Z","timestamp":1788184395421,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuropsychology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The differentiation of subtypes of primary progressive aphasia (PPA) remains challenging. We aimed to identify optimum neuropsychological measures for characterizing PPA, to examine the relationship between behavioural change and subtypes of PPA and to determine whether characteristic profiles of language, working memory, and behavioural changes occur in PPA. Forty\u2010seven patients with PPA and multi\u2010domain Alzheimer's disease (AD) together with 19 age\u2010matched controls underwent a large battery of working memory and language tests. We found that simple tasks of sentence ordering, narrative production, and buccofacial praxis were particularly useful in differentiating non\u2010fluent\/agrammatic variant PPA (nfvPPA) from other PPA subtypes, whereas a test of single word comprehension was useful in detecting semantic dementia (SD). No individual tests were discriminating for logopenic variant PPA (lvPPA) relative to nfvPPA. LvPPA and multidomain AD exhibited similar language profiles. A principal components analysis revealed that characteristic PPA profiles extended beyond the realms of language, in particular, the presence of apraxia in nfvPPA, behavioural changes in SD, and working memory deficits in lvPPA. These findings suggest that not all tests are equally discriminatory for PPA and highlight the importance of a test profile in differentiating PPA. These results also support the view that lvPPA is a focal form of AD and emphasize the difficulties classifying lvPPA.<\/jats:p>","DOI":"10.1111\/jnp.12149","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T23:56:51Z","timestamp":1518134211000},"page":"214-239","source":"Crossref","is-referenced-by-count":35,"title":["Neuropsychological differentiation of progressive aphasic disorders"],"prefix":"10.1111","volume":"13","author":[{"given":"Jennifer M.","family":"Harris","sequence":"first","affiliation":[{"name":"Manchester Academic Health Sciences Centre Cerebral Function Unit Greater Manchester Neuroscience Centre Salford Royal NHS Foundation Trust UK"},{"name":"Division of Neurosciences and Experimental Psychology Faculty of Biology, Medicine and Health University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Saxon","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Sciences Centre Cerebral Function Unit Greater Manchester Neuroscience Centre Salford Royal NHS Foundation Trust UK"},{"name":"Division of Neurosciences and Experimental Psychology Faculty of Biology, Medicine and Health University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Jones","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Sciences Centre Cerebral Function Unit Greater Manchester Neuroscience Centre Salford Royal NHS Foundation Trust UK"},{"name":"Division of Neurosciences and Experimental Psychology Faculty of Biology, Medicine and Health University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie S.","family":"Snowden","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Sciences Centre Cerebral Function Unit Greater Manchester Neuroscience Centre Salford Royal NHS Foundation Trust UK"},{"name":"Division of Neurosciences and Experimental Psychology Faculty of Biology, Medicine and Health University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Sciences Centre Cerebral Function Unit Greater Manchester Neuroscience Centre Salford Royal NHS Foundation Trust UK"},{"name":"Division of Neurosciences and Experimental Psychology Faculty of Biology, Medicine and Health University of Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302798"},{"key":"e_1_2_7_3_1","first-page":"23","article-title":"The observation to variable ratio in factor analysis","volume":"1","author":"Barrett P. 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