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Such \u2018relational processing\u2019 enables us to (re)construct episodic representations of real or imagined events. The present study examined whether hippocampally mediated relational processing also contributes to the construction of semantic representations. To do so, we asked amnesic individuals with medial temporal lobe (MTL) lesions including the hippocampus to generate hypothetical meanings for novel word compounds (e.g., cactus carpet), a task that requires existing concepts to be flexibly linked. The quality of definitions and number of features generated for the novel compounds were lower in patients with MTL lesions than in control participants. Whereas the subset of patients with lesions extending into lateral temporal cortex had additional difficulty generating meanings for pre\u2010existing compounds (e.g., bus station), patients with lesions limited to the MTL showed no such deficit, indicating that their impairment in the novel compound condition was not due to reduced access to semantic information. These findings suggest that the role of hippocampally mediated relational processing extends beyond the episodic domain to include the generation of novel semantic representations.<\/jats:p>","DOI":"10.1111\/jnp.12196","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T02:57:47Z","timestamp":1573786667000},"page":"416-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relational processing in the semantic domain is impaired in medial temporal lobe amnesia"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-6771","authenticated-orcid":false,"given":"Margaret M.","family":"Keane","sequence":"first","affiliation":[{"name":"Department of Psychology Wellesley College Massachusetts USA"},{"name":"Memory Disorders Research Center VA Boston Healthcare System and Boston University School of Medicine Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Memory Disorders Research Center VA Boston Healthcare System and Boston University School of Medicine Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey","family":"Wank","sequence":"additional","affiliation":[{"name":"Memory Disorders Research Center VA Boston Healthcare System and Boston University School of Medicine Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-4584","authenticated-orcid":false,"given":"Mieke","family":"Verfaellie","sequence":"additional","affiliation":[{"name":"Memory Disorders Research Center VA Boston Healthcare System and Boston University School of Medicine Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00325"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.04.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2011.00173"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-56591-8_10"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.10.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2017.01.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-013-0403-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0019749"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22208"},{"key":"e_1_2_8_13_1","volume-title":"From conditioning to conscious recollection","author":"Eichenbaum H.","year":"2001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15516709cog2706_4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03211572"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/4.4.344"},{"key":"e_1_2_8_17_1","first-page":"637","article-title":"Methods for normalization of hippocampal volumes measured with MR","volume":"16","author":"Free S. 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