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Insight into outcome\u2010based learning capacity may be relevant for optimizing the learning potential of these patients. To date, mixed results have been found in studies in which cognitively impaired participants have to learn based on positive and negative outcomes. In this study, we investigated the role of negative and positive feedback on memory performance and participants' ability to adjust their behaviour accordingly in a sample of 23 early\u2010stage AD patients and 23 matched healthy controls. We administered a novel computerized object\u2010location memory task, in which participants were instructed to learn and memorize the locations of different everyday objects following errorless learning (EL) and trial\u2010and\u2010error learning (TEL). A separate probabilistic TEL task was employed in which participants had to learn how to adjust their behaviour based on positive and negative feedback. EL had a beneficial general effect on memory performance for object locations. However, this effect was not larger in early\u2010stage AD patients compared to controls and error frequency during acquisition of object locations was unrelated to later recall performance. No group differences were found on the probabilistic learning task with respect to learning performance over time and based on positive and negative feedback. Although the error monitoring system seems intact in patients with early\u2010stage AD, errors during learning are likely acting as a source of interference causing difficulty in storage or retrieval of object locations.<\/jats:p>","DOI":"10.1111\/jnp.12330","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T13:18:55Z","timestamp":1686835135000},"page":"100-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Learning capacity in early\u2010stage Alzheimer's disease: The role of feedback during learning on memory performance"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-5736","authenticated-orcid":false,"given":"Inge","family":"Scheper","sequence":"first","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour Radboud University  Nijmegen The Netherlands"},{"name":"Department of Medical Psychology Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Center for Psychiatry, GGZ Centraal  Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-0902","authenticated-orcid":false,"given":"Inti A.","family":"Brazil","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour Radboud University  Nijmegen The Netherlands"},{"name":"Division Diagnostics, Research, &amp; Education Forensic Psychiatric Centre Pompestichting  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-8151","authenticated-orcid":false,"given":"Jurgen A. 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