{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:48:37Z","timestamp":1790977717559,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09174"],"award-info":[{"award-number":["21K09174"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspsychub.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuropsychology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with diffuse frontal gliomas often present with post\u2010operative apathy after tumour removal. However, the association between apathy and tumour removal of gliomas from the frontal lobe remains unknown. This study aimed to investigate the factors influencing post\u2010operative apathy after tumour removal in patients with diffuse frontal gliomas. We compared the demographics and clinical characteristics of patients with and without post\u2010operative apathy in a cohort of 54 patients who underwent awake brain mapping for frontal gliomas. The frequency of clinical parameters such as left\u2010sided involvement, high\u2010grade tumour types (WHO grades III, IV), main tumour location in the anterior cingulate gyrus (ACC) and\/or dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) was significantly greater in the apathetic group compared to the non\u2010apathetic group. The apathetic group scored significantly lower on neuropsychological assessments such as the Letter Fluency Test among the Word Fluency Tests than the non\u2010pathetic group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.000). Moreover, the scores of Parts 3, and 3\u20131 of the Stroop test were significantly lower in the apathetic group than those in the non\u2010apathetic group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.023, .027, respectively). Multivariate model analysis revealed that the appearance of post\u2010operative apathy was significantly related to side of the of lesion [left vs. right, hazard ratio (HR)\u2009=\u20098.00, 95% confidence interval (CI)\u2009=\u20091.36\u201346.96,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.021], location of the main tumour in the frontal lobe (ACC\/DLPFC\/OFC vs. others, HR\u2009=\u20097.99, 95% CI\u2009=\u20092.16\u201329.59,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.002), and the Letter Fluency Test (HR\u2009=\u2009.37, 95% CI\u2009=\u2009.15\u2013.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.028). Post\u2010operative apathy is significantly associated with ACC and\/or DLPFC and OFC in the left hemisphere of diffuse frontal gliomas. Apathy in frontal gliomas is correlated with a decline in the Letter Fluency Test scores. Therefore, this instrument is a potential predictor of post\u2010operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping.\n                  <\/jats:p>","DOI":"10.1111\/jnp.12345","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:59:11Z","timestamp":1695257951000},"page":"73-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive factors of post\u2010operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-1104","authenticated-orcid":false,"given":"Kazuya","family":"Motomura","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Nagoya University School of Medicine  Nagoya Japan"},{"name":"Department of Rehabilitation Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Nagoya University Hospital  Nagoya Japan"},{"name":"Department of Behavioral Neurology &amp; Cognitive Neuroscience Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiharu","family":"Ohka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya University School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya University School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohide","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagoya University School of Medicine  Nagoya 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