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However, few studies have examined whether decision\u2010making under ambiguity is an endophenotype of OCD. This study aimed to investigate decision\u2010making under ambiguity, as assessed by the Iowa Gambling Task (IGT), in patients with OCD and unaffected first\u2010degree relatives (UFDR). Forty\u2010seven non\u2010medicated, non\u2010co\u2010morbid patients with OCD, 30 UFDR, and 47 healthy controls (HC) were compared in terms of decision\u2010making using the IGT. The correlation between obsessive\u2010compulsive symptoms and IGT performance was also investigated. Patients with OCD and UFDR performed worse than HC on the IGT. No correlation was found between obsessive\u2010compulsive symptoms and IGT performance. A deficit in decision\u2010making under ambiguity may be a trait and an endophenotype candidate for OCD.<\/jats:p>","DOI":"10.1111\/jnp.12407","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T23:49:31Z","timestamp":1734479371000},"page":"274-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Decision\u2010making using the Iowa gambling test in unaffected first\u2010degree relatives of obsessive\u2010compulsive disorder: Comparison with healthy controls and patients with obsessive\u2010compulsive disorder"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-6823","authenticated-orcid":false,"given":"Keitaro","family":"Murayama","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Kyushu University Hospital  Fukuoka 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