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However, early results have been variable due to oversimplified approaches. This manuscript explores the potential and complexities of tES, particularly focusing on a protocol defined transcranial direct current stimulation as a reference model for all tES protocols, emphasising the need for precision in tailoring stimulation parameters to individual characteristics. By integrating intrinsic (i.e. the neuro\u2010physiological system state) and extrinsic factors (i.e. experimental set up), highlighting the critical role of state\u2010dependent effects and the synergy with cognitive tasks, we aim to refine tES protocols. This approach not only addresses the complexity of the brain system (as defined by its current state) but also highlights the importance of collaborative research and data sharing to understand the underlying mechanisms of tES\u2010induced changes and optimising therapeutic efficacy. Emphasising the integration of tES with targeted tasks and clearer hypotheses, this work underscores the potential for more effective neurorehabilitation strategies.<\/jats:p>","DOI":"10.1111\/jnp.12425","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T01:33:02Z","timestamp":1742779982000},"page":"655-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Learning from missteps: Potential of transcranial electrical stimulation in neuropsychological rehabilitation"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5436-4745","authenticated-orcid":false,"given":"Carlo","family":"Miniussi","sequence":"first","affiliation":[{"name":"Center for Mind\/Brain Sciences\u2014CIMeC University of Trento  Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Pellicciari","sequence":"additional","affiliation":[{"name":"Department of Human Sciences LUMSA University  Rome 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