{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:24Z","timestamp":1788876564914,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspsychub.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuropsychology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) associated with cognitive and functional impairment. Longitudinal studies have examined the associations between apathy and cognition in AD and other dementias, but more information is needed to understand whether the relationships are consistent longitudinally, and whether apathy relates to decline in AD\u2010related cognitive domains or to drop\u2010out rates in the follow\u2010up. We used data from 236 people (age M\u2009=\u200975.15 and 51.3% female at baseline) with very mild or mild AD from the Finnish ALSOVA study with up to 5\u2009years of follow\u2010up. Global cognition was measured with the Consortium to Establish a Registry for Alzheimer's disease\u2010Neuropsychological Battery, apathy with the Neuropsychiatric Inventory, and disease severity with the Clinical Dementia Rating\u2010Sum of Boxes. Associations between cognition and apathy were examined with correlation analyses, linear regression analyses and linear mixed models. In longitudinal analyses, we found that apathy was associated with worse global cognition (\n                    <jats:italic>B<\/jats:italic>\n                    \u2009=\u2009\u22120.39, SE\u2009=\u20090.12,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001) after adjusting for disease severity. However, apathy and global cognition were not consistently associated with one another in cross\u2010sectional analyses. Older age (OR\u2009=\u20090.95,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.02), but not apathy, was associated with a lower likelihood of participating in the final follow\u2010up visit. In conclusion, apathy associates with worse global cognition longitudinally, but when examined cross\u2010sectionally, the apathy\u2010cognition associations are inconsistent. Apathy at baseline does not seem to affect drop\u2010out rates in a long follow\u2010up of individuals with very mild or mild AD.\n                  <\/jats:p>","DOI":"10.1111\/jnp.70044","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:45:26Z","timestamp":1774867526000},"page":"533-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between apathy and global cognition in a 5\u2010year follow\u2010up of individuals with Alzheimer's disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Henna\u2010Riikka","family":"Loukola","sequence":"first","affiliation":[{"name":"School of Educational Sciences and Psychology University of Eastern Finland  Joensuu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maikki","family":"K\u00e4rkk\u00e4inen","sequence":"additional","affiliation":[{"name":"School of Educational Sciences and Psychology University of Eastern Finland  Joensuu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Selander","sequence":"additional","affiliation":[{"name":"Science Services Center Kuopio University Hospital, Wellbeing Services County of North Savo  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Honkalampi","sequence":"additional","affiliation":[{"name":"School of Educational Sciences and Psychology University of Eastern Finland  Joensuu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Koivisto","sequence":"additional","affiliation":[{"name":"NeuroCenter, Neurology Kuopio University Hospital  Kuopio Finland"},{"name":"Departments of Geriatrics and Neurology, Helsinki University Hospital and Department of Neurosciences, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-3336","authenticated-orcid":false,"given":"Toni T.","family":"Saari","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland, HiLIFE University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"11","article-title":"Frontal\u2010subcortical circuitry and behavior","volume":"9","author":"Bonelli R. 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