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Antibodies to contactin\u2010associated protein\u2010like 2 (<jats:styled-content style=\"fixed-case\">CASPR2<\/jats:styled-content>), part of the voltage\u2010gated potassium channel complex (<jats:styled-content style=\"fixed-case\">VGKC<\/jats:styled-content>\u2010complex), are associated with neurological disease predominantly affecting the peripheral nervous system but are not known to be associated with <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>. We report two cases of ganglioside antibody\u2010negative paediatric <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">CASPR2<\/jats:styled-content> antibodies. Both patients made a complete clinical recovery. The tissue distribution and function of <jats:styled-content style=\"fixed-case\">CASPR2<\/jats:styled-content> make it a biologically plausible autoimmune target in <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and its clinical relevance in <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> should be determined in further studies.<\/jats:p>","DOI":"10.1111\/jns.12089","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T07:04:32Z","timestamp":1416553472000},"page":"246-249","source":"Crossref","is-referenced-by-count":18,"title":["Guillain\u2010Barr\u00e9 syndrome associated with <scp>CASPR2<\/scp> antibodies: two paediatric cases"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0316-5818","authenticated-orcid":false,"given":"Richard E.","family":"Rosch","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences Institute of Psychiatry, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-229X","authenticated-orcid":false,"given":"Alasdair","family":"Bamford","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Hacohen","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford, John Radcliffe Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wraige","sequence":"additional","affiliation":[{"name":"Children's Neurosciences, Evelina Children's Hospital Kings Health Partners Academic Health Science Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford, John Radcliffe Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Mewasingh","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lim","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford, John Radcliffe Hospital  Oxford UK"},{"name":"Children's Neurosciences, Evelina Children's Hospital Kings Health Partners Academic Health Science Centre  London 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