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Levodopa\u2010induced vitamin <jats:styled-content style=\"fixed-case\">B12<\/jats:styled-content> deficiency has been discussed as a causal factor of <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> in idiopathic Parkinson's disease, but peripheral nervous system involvement might also be a consequence of the underlying neurodegenerative process. Occurrence of <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> with parkinsonism has been associated with a panel of mitochondrial cytopathies, more frequently related to a nuclear gene defect and mainly polymerase gamma (<jats:italic><jats:styled-content style=\"fixed-case\">POLG1<\/jats:styled-content><\/jats:italic>) gene. Parkin (<jats:italic><jats:styled-content style=\"fixed-case\">PARK2<\/jats:styled-content><\/jats:italic>) gene mutations are responsible for juvenile parkinsonism, and possible peripheral nervous system involvement has been reported. Rarely, an association of parkinsonism with <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> may be encountered in other neurodegenerative diseases such as fragile X\u2010associated tremor and ataxia syndrome related to premutation <jats:styled-content style=\"fixed-case\">CGG<\/jats:styled-content> repeat expansion in the fragile X mental retardation (<jats:italic><jats:styled-content style=\"fixed-case\">FMR1<\/jats:styled-content><\/jats:italic>) gene, Machado\u2013Joseph disease related to an abnormal <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeat expansion in ataxin\u20103 (<jats:italic><jats:styled-content style=\"fixed-case\">ATXN3<\/jats:styled-content><\/jats:italic>) gene, Kufor\u2013Rakeb syndrome caused by mutations in <jats:italic><jats:styled-content style=\"fixed-case\">ATP13A2<\/jats:styled-content><\/jats:italic> gene, or in hereditary systemic disorders such as Gaucher disease due to mutations in the \u03b2\u2010glucocerebrosidase (<jats:italic><jats:styled-content style=\"fixed-case\">GBA<\/jats:styled-content><\/jats:italic>) gene and Chediak\u2013Higashi syndrome due to <jats:italic><jats:styled-content style=\"fixed-case\">LYST<\/jats:styled-content><\/jats:italic> gene mutations. This article reviews conditions in which <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> may coexist with parkinsonism.<\/jats:p>","DOI":"10.1111\/jns.12099","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T12:21:29Z","timestamp":1421151689000},"page":"333-342","source":"Crossref","is-referenced-by-count":17,"title":["Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum"],"prefix":"10.1111","volume":"19","author":[{"given":"Anne","family":"Vital","sequence":"first","affiliation":[{"name":"University of Bordeaux  Bordeaux France"},{"name":"CNRS Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives  Bordeaux France"},{"name":"Department of Pathology Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Lepreux","sequence":"additional","affiliation":[{"name":"Department of Pathology Bordeaux University Hospital  Bordeaux 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