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Exercise may be beneficial to maintain strength and function for people with <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content>, however, no comprehensive evaluation of the benefits and risks of exercise have been conducted. A systematic review was completed searching numerous electronic databases from earliest records to February 2015. Studies of any design including participants of any age with confirmed diagnosis of <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content> that investigated the effects of exercise were eligible for inclusion. Of 13,301 articles identified following removal of duplicates, 11 articles including 9 unique studies met the criteria. Methodological quality of studies was moderate, sample sizes were small, and interventions and outcome measures used varied widely. Although the majority of the studies identified changes in one or more outcome measurements across exercise modalities, the majority were non\u2010significant, possibly due to Type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> errors. Significant effects described included improvements in strength, functional activities, and physiological adaptations following exercise. Despite many studies showing changes in strength and function following exercise, findings of this review should be met with caution due to the few studies available and moderate quality of evidence. Well\u2010powered studies, harmonisation of outcome measures, and clearly described interventions across studies would improve the quality and comparability of the evidence base. The optimal exercise modality and intensity for people with <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content> as well as the long\u2010term safety of exercise remain unclear.<\/jats:p>","DOI":"10.1111\/jns.12116","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T13:29:04Z","timestamp":1432301344000},"page":"347-362","source":"Crossref","is-referenced-by-count":67,"title":["Systematic review of exercise for Charcot\u2010Marie\u2010Tooth disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Amy D.","family":"Sman","sequence":"first","affiliation":[{"name":"Institute for Neuroscience and Muscle Research The Children's Hospital at Westmead  Westmead Australia"},{"name":"Discipline of Physiotherapy, Faculty of Health Sciences The University of Sydney  Lidcombe Australia"},{"name":"Paediatric Gait Analysis Service of New South Wales Sydney Children's Hospitals Network (Randwick and Westmead)  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hackett","sequence":"additional","affiliation":[{"name":"Discipline of Exercise and Sport Science, Faculty of Health Sciences The University of Sydney  Lidcombe Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fiatarone Singh","sequence":"additional","affiliation":[{"name":"Discipline of Exercise and Sport Science, Faculty of Health Sciences The University of Sydney  Lidcombe Australia"},{"name":"Sydney Medical School &amp; Charles Perkins Centre The University of Sydney  Camperdown Australia"},{"name":"Hebrew Senior Life, and Jean Meyer USDA Human Nutrition Research Center on Aging Tufts University  Boston MA 02111 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ch\u00e9","family":"Fornusek","sequence":"additional","affiliation":[{"name":"Discipline of Exercise and Sport Science, Faculty of Health Sciences The University of Sydney  Lidcombe Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj P.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Muscle Research The Children's Hospital at Westmead  Westmead Australia"},{"name":"T.Y. Nelson Department of Neurology &amp; Neurosurgery The Children's Hospital at Westmead  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Burns","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Muscle Research The Children's Hospital at Westmead  Westmead Australia"},{"name":"Discipline of Physiotherapy, Faculty of Health Sciences The University of Sydney  Lidcombe Australia"},{"name":"Paediatric Gait Analysis Service of New South Wales Sydney Children's Hospitals Network (Randwick and Westmead)  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.06.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.09.012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23771"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.02.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.09.007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2003.12.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20078"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.07.024"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0b013e3181990fcc"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181949333"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20959"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198410000-00007"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.09.054"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(95)80629-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-6411(99)00003-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3310\/hta4340","article-title":"A systematic review of comparison of effect sizes derived from randomised and non\u2010randomised studies","volume":"4","author":"MacLehose R","year":"2000","journal-title":"Health Technol Assess"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31821f6e32"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280600646169"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.09.008"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665109991741"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2006.04054.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70110-3"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307598"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0274"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12100"},{"key":"e_1_2_5_30_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. 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