{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:57:19Z","timestamp":1791593839033,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GBS-CIDP International Foundation"},{"name":"Talecris Talents Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to \u2018define responder\u2019 through the concept of minimum clinically important differences using the individually obtained standard errors (<jats:styled-content style=\"fixed-case\">MCID\u2010SE<\/jats:styled-content>) and a heuristic \u2018external criterion\u2019 responsiveness method in patients with Guillain\u2010Barr\u00e9 syndrome (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) and chronic inflammatory demyelinating polyradiculoneuropathy (<jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content>). One hundred and fourteen newly diagnosed or relapsing patients (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>: 55, <jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content>: 59) were serially examined (1\u2010year follow\u2010up). The inflammatory Rasch\u2010built overall disability scale (I\u2010<jats:styled-content style=\"fixed-case\">RODS<\/jats:styled-content>), Rasch\u2010transformed <jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content> sum score (<jats:styled-content style=\"fixed-case\">RT\u2010MRC<\/jats:styled-content>), and Rasch\u2010transformed modified\u2010<jats:styled-content style=\"fixed-case\">INCAT<\/jats:styled-content>\u2010sensory scale (<jats:styled-content style=\"fixed-case\">RT\u2010mISS<\/jats:styled-content>) were assessed. Being\u2010a\u2010responder was defined as having a <jats:styled-content style=\"fixed-case\">MCID\u2010SE<\/jats:styled-content> cut\u2010off \u22651.96. Also, the correlations between patients' scores on each scale and the <jats:styled-content style=\"fixed-case\">EuroQoL<\/jats:styled-content> health\u2010status \u2018thermometer\u2019 (external criterion) were determined (higher correlation indicated better responsiveness). In both diseases, the <jats:styled-content style=\"fixed-case\">SEs<\/jats:styled-content> showed a characteristic \u2018U\u2019\u2010shaped dynamic pattern across each scales' continuum. The number of patients showing a meaningful change were higher for the I\u2010<jats:styled-content style=\"fixed-case\">RODS<\/jats:styled-content>\u2009&gt;\u2009<jats:styled-content style=\"fixed-case\">RT\u2010MRC<\/jats:styled-content>\u2009&gt;\u2009<jats:styled-content style=\"fixed-case\">RT\u2010mISS<\/jats:styled-content> and were in <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> higher than <jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content> patients. The <jats:styled-content style=\"fixed-case\">MCID\u2010SE<\/jats:styled-content> concept using Rasch\u2010transformed data demonstrated an individual pattern of \u2018being\u2010a\u2010responder\u2019 in patients with immune\u2010mediated neuropathies, and the findings were validated by the external criterion responsiveness method. The I\u2010<jats:styled-content style=\"fixed-case\">RODS<\/jats:styled-content> showed greater responsiveness compared with the <jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">INCAT<\/jats:styled-content>\u2010sensory scales, and its use is therefore recommended in future trials in <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jns.12118","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T10:45:28Z","timestamp":1435315528000},"page":"289-295","source":"Crossref","is-referenced-by-count":47,"title":["Impairment measures versus inflammatory <scp>RODS<\/scp> in <scp>GBS<\/scp> and <scp>CIDP<\/scp>: a responsiveness comparison"],"prefix":"10.1111","volume":"20","author":[{"given":"Els K.","family":"Vanhoutte","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics University Medical Centre Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H. 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