{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:20:05Z","timestamp":1789194005503,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T00:00:00Z","timestamp":1449964800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the clinical, electrophysiological, and pathological features, outcome, and frequency of anti\u2010tumor necrosis factor alpha (a\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>) medications\u2010induced neuropathies (<jats:styled-content style=\"fixed-case\">ATIN<\/jats:styled-content>) in patients with inflammatory disorders. Of 2,017 patients treated with a\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> medication, 12 patients met our inclusion criteria for a prevalence of 0.60% and an incidence of 0.4 cases per 1,000 person\u2010years. The median time from a\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> medication treatment to <jats:styled-content style=\"fixed-case\">ATIN<\/jats:styled-content> was 16.8\u2009months (range 2\u201360 months). Six patients had focal or multifocal peripheral neuropathies. The other six had generalized neuropathies. For all, a\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> medication was stopped. Seven patients received immunoglobulin infusions. <jats:styled-content style=\"fixed-case\">ATIN<\/jats:styled-content> outcome was favorable in all but one patient. <jats:styled-content style=\"fixed-case\">ATINs<\/jats:styled-content> are rare and heterogeneous neuropathies. In 10 patients, the neuropathy was \u201cinflammatory\u201d, suggesting that it could be due to systemic pro\u2010inflammatory effects of a\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> agents.<\/jats:p>","DOI":"10.1111\/jns.12147","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T08:55:29Z","timestamp":1440579329000},"page":"397-402","source":"Crossref","is-referenced-by-count":37,"title":["Anti\u2010TNF alpha medications and neuropathy"],"prefix":"10.1111","volume":"20","author":[{"given":"Pinelopi","family":"Tsouni","sequence":"first","affiliation":[{"name":"Nerve\u2010Muscle Unit, Department of Clinical Neurosciences Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bill","sequence":"additional","affiliation":[{"name":"Nerve\u2010Muscle Unit, Department of Clinical Neurosciences Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Truffert","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Neurosciences University Hospital of Geneva (HUG)  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Liaudat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Ochsner","sequence":"additional","affiliation":[{"name":"Nerve\u2010Muscle Unit, Department of Clinical Neurosciences Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Steck","sequence":"additional","affiliation":[{"name":"Nerve\u2010Muscle Unit, Department of Clinical Neurosciences Lausanne University Hospital (CHUV)  Lausanne Switzerland"},{"name":"Department of Neurology Basel University Hospital  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Kuntzer","sequence":"additional","affiliation":[{"name":"Nerve\u2010Muscle Unit, Department of Clinical Neurosciences Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21584"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.457"},{"key":"e_1_2_6_4_1","first-page":"S13","article-title":"Immunomodulatory or immunosuppressive\u2010induced neuropathies","volume":"18","author":"Bill O","year":"2013","journal-title":"J Peripher Nerv Syst"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00245.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh429"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4582"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.11"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31822b7bb8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1841-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs067"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158681.29117.8B"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes375"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.23011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.867358"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20924"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2419-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5591-7"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:41:21Z","timestamp":1696254081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jns.12147"],"URL":"https:\/\/doi.org\/10.1111\/jns.12147","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}