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We investigated the contribution of adenosine subtypes to the antihyperalgesic effect of gabapentin by examining the effect of caffeine, a non\u2010selective adenosine<jats:styled-content style=\"fixed-case\">A<jats:sub>1<\/jats:sub><\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">A<jats:sub>2<\/jats:sub><\/jats:styled-content>receptor antagonist or 1,3\u2010dipropyl\u20108\u2010cyclopentylxanthine (<jats:styled-content style=\"fixed-case\">DPCPX<\/jats:styled-content>), a selective adenosine<jats:styled-content style=\"fixed-case\">A<jats:sub>1<\/jats:sub><\/jats:styled-content>subtype receptor antagonist on this effect. Neuropathic pain was produced by unilateral prolonged hind paw ischemia and reperfusion (I\/R) or<jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content>procedures which resulted in stimulus\u2010evoked mechanical hyperalgesia. After procedures, animals received gabapentin (10, 30, or 100 mg\/kg intraperitoneal, respectively), caffeine (10\u2009mg\/kg intraperitoneal or 150\u2009nmol intrathecally) or<jats:styled-content style=\"fixed-case\">DPCPX<\/jats:styled-content>(3\u2009\u00b5g intrathecally) alone or in combination. Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures. Gabapentin produced dose\u2010related inhibition of mechanical hyperalgesia over a 3\u2010week period, and this effect was blocked by concomitant caffeine or<jats:styled-content style=\"fixed-case\">DPCPX<\/jats:styled-content>administration 1 week after injuries. The results of this study demonstrated that the mechanism through which gabapentin produces its effect may involve the activation of adenosine<jats:styled-content style=\"fixed-case\">A<jats:sub>1<\/jats:sub><\/jats:styled-content>subtype receptor.<\/jats:p>","DOI":"10.1111\/jns.12149","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T22:48:44Z","timestamp":1444690124000},"page":"403-409","source":"Crossref","is-referenced-by-count":24,"title":["Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of<scp>CRPS<\/scp>\u2010I: evidence for the involvement of spinal adenosine<scp>A<sub>1<\/sub><\/scp>receptor"],"prefix":"10.1111","volume":"20","author":[{"given":"Daniel F.","family":"Martins","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program of Health Sciences University of Southern Santa Catarina Palho\u00e7a Santa Catarina Brazil"},{"name":"Experimental Neuroscience Laboratory University of Southern Santa Catarina Palho\u00e7a Santa Catarina Brazil"},{"name":"Undergraduate Course of Medicine University of Southern Santa Catarina Palho\u00e7a Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos R. 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