{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T01:54:46Z","timestamp":1761789286239},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The \u201cability to walk\u201d is considered a benchmark for good clinical recovery and prognosis, particularly in patients with Guillain\u2010Barr\u00e9 syndrome (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) and chronic inflammatory demyelinating polyradiculoneuropathy (<jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content>). However, it has never been determined whether being \u201cable to walk\u201d represents general functionality. The purpose of this study was to examine whether the ability to walk outside independently reflects general functional improvement in patients with <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content>, and gammopathy\u2010related neuropathy (<jats:styled-content style=\"fixed-case\">MGUSP<\/jats:styled-content>). A total of 137 patients with newly diagnosed (or relapsing) <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> (55), <jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content> (59), and <jats:styled-content style=\"fixed-case\">MGUSP<\/jats:styled-content> (23) were serially examined (1\u2010year). Predefined arbitrary cut\u2010offs (so\u2010called patients' Functional\u2010Acceptable\u2010Clinical\u2010Thresholds [<jats:styled-content style=\"fixed-case\">FACTs<\/jats:styled-content>]) were taken at the 50th, 75th, and 90th percentile of the Inflammatory\u2010Rasch\u2010built\u2010Overall\u2010Disability\u2010Scale (I\u2010<jats:styled-content style=\"fixed-case\">RODS<\/jats:styled-content><jats:sup>\u00a9<\/jats:sup>). We determined the proportion of patients able to walk outside independently that reached the postulated cut\u2010offs. A mean total of 85%, 39%, and 12% of all patients able to walk reached 50th, 75th, and 90th percentile thresholds, respectively. These findings were not neuropathy type related. Our findings show that assessing only one construct of functionality (e.g., walking ability) does not reflect the full scope of daily\/social functional deficits perceived by patients. The ability to walk shows a patient is doing better, but not necessarily doing well. The I\u2010<jats:styled-content style=\"fixed-case\">RODS<\/jats:styled-content><jats:sup>\u00a9<\/jats:sup> bypasses these limitations.<\/jats:p>","DOI":"10.1111\/jns.12167","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:30:11Z","timestamp":1457767811000},"page":"74-81","source":"Crossref","is-referenced-by-count":15,"title":["Does ability to walk reflect general functionality in inflammatory neuropathies?"],"prefix":"10.1111","volume":"21","author":[{"given":"Thomas H. P.","family":"Draak","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Centre Maastricht  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth C.","family":"Gorson","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Elizabeth's Medical Centre, Tufts University School of Medicine  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els K.","family":"Vanhoutte","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja I.","family":"van Nes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Havenziekenhuis  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus Medical Centre Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Cornblath","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard H.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Neurology Rudolf Magnus Institute of Neuroscience University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina G.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Centre Maastricht  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar S. J.","family":"Merkies","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Centre Maastricht  Maastricht The Netherlands"},{"name":"Department of Neurology Spaarne Hospital  Hoofddorp The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PeriNomS Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-0808-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10305"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.7.1098"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.1.57"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.4.1067"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11015.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1088"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1324"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12080"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.03.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000092019.53628.88"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868527"},{"key":"e_1_2_6_16_1","first-page":"2025","article-title":"Minimal clinically important difference, low disease activity state, and patient acceptable symptom state: methodological issues","volume":"32","author":"Tubach F","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22110"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.121"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204233261705"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15324-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318208824b"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.06.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.774"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12167","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T05:06:01Z","timestamp":1695704761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/jns.12167"],"URL":"https:\/\/doi.org\/10.1111\/jns.12167","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"type":"print","value":"1085-9489"},{"type":"electronic","value":"1529-8027"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}