{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:31:28Z","timestamp":1775676688680,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hand weakness and impaired manual dexterity have been reported in children with Charcot\u2010Marie\u2010Tooth disease type <jats:styled-content style=\"fixed-case\">1A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CMT1A<\/jats:styled-content>). This early onset of upper limb involvement might explain frequent clinical referrals for assessment and treatment of impaired handwriting performance. The aim of this study was to examine the impact of <jats:styled-content style=\"fixed-case\">CMT1A<\/jats:styled-content> on handwriting speed and legibility, and identify demographic, anthropometric, and physical measures that might relate to handwriting performance. Handwriting speed (Handwriting Speed Test), handwriting legibility (Evaluation Tool of Children's Handwriting\u2010Cursive), and hand strength (hand\u2010held dynamometry of tip pinch, lateral pinch and grip) were assessed in 30 children with <jats:styled-content style=\"fixed-case\">CMT1A<\/jats:styled-content> (aged 8\u201317 years) and 30 age\u2010 and sex\u2010matched controls. Children with <jats:styled-content style=\"fixed-case\">CMT1A<\/jats:styled-content> exhibited 34% slower handwriting speed (p &lt; 0.0001) with 4% reduced legibility (p = 0.001) and 37\u201348% lower hand strength (p &lt; 0.0001). All measures of strength, age, height, and weight were positively associated with handwriting speed (r = 0.39\u20130.79, p &lt; 0.01). None of these factors related to handwriting legibility (p &gt; 0.05). Regression modelling identified a diagnosis of <jats:styled-content style=\"fixed-case\">CMT1A<\/jats:styled-content>, lateral pinch weakness and younger age as significant independent predictors of slower handwriting speed, explaining 78% of the variance. Children with <jats:styled-content style=\"fixed-case\">CMT1A<\/jats:styled-content> have considerable handwriting difficulties, primarily with speed, and substantial associated hand and finger weakness. Understanding the cause\u2013effect relationship between strength and function might provide modifiable targets for upper limb intervention.<\/jats:p>","DOI":"10.1111\/jns.12198","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T09:58:38Z","timestamp":1480931918000},"page":"34-38","source":"Crossref","is-referenced-by-count":6,"title":["Handwriting difficulties of children with Charcot\u2010Marie\u2010Tooth disease type <scp>1A<\/scp>"],"prefix":"10.1111","volume":"22","author":[{"given":"Daniel","family":"Kunovsky","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinie","family":"Cordier","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Curtin University  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Bray","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Sydney  Sydney NSW Australia"},{"name":"Sydney Children's Hospitals Network (Randwick and Westmead)  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Burns","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Sydney  Sydney NSW Australia"},{"name":"Sydney Children's Hospitals Network (Randwick and Westmead)  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Evaluation Tool of Children's Handwriting","author":"Amundson SJ","year":"1995"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.08.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.64.1.37"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00312.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2182\/cjot.2011.78.1.3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1123\/mcj.5.2.200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2012.004515"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.09.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.34282"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280701400755"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0419"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.187302"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/J006v19n01_03"},{"key":"e_1_2_6_15_1","first-page":"146","article-title":"Writing legibly and quickly: a study of children's ability to adjust their handwriting to meet common classroom demands","volume":"13","author":"Weintraub N","year":"1998","journal-title":"Learning Disabilities Research and Practice"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:51:42Z","timestamp":1696161102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/jns.12198"],"URL":"https:\/\/doi.org\/10.1111\/jns.12198","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}