{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:32:36Z","timestamp":1780119156695,"version":"3.54.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neuroprotective effect of epidermal growth factor (EGF) has been documented in different contexts, but its potential benefits in peripheral neuropathies have been little studied. We investigated the neuroprotective action of EGF in experimental neuropathy induced by acrylamide (ACR). Mice and rats were treated chronically with acrylamide for 6 and 8 weeks, respectively. Concurrently they received EGF in daily doses of 1 and 5 mg\/kg in mice and 3 mg\/kg in rats, or saline (PBS). ACR severely affected the neurological score, the muscle strength, and the muscle potential M, in mice, as well as F\u2010waves (F\u2010Wii), sensory potentials (SPii), and apomorphine\u2010induced penile erection, in rats. EGF reduced the ACR effects in both species. A dose\u2010dependent effect of EGF was manifested in the proportion of diseased animals at the end of treatments, as well as in the reduction of M amplitude throughout the treatment. F\u2010Wii parameters were less protected by EGF than SP. The results show a protective effect of EGF in acrylamide\u2010induced neuropathy and support previous studies concerning the neuroprotective action of this peptide.<\/jats:p>","DOI":"10.1111\/jns.12214","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T06:53:16Z","timestamp":1493016796000},"page":"106-111","source":"Crossref","is-referenced-by-count":10,"title":["Neuroprotective effect of epidermal growth factor in experimental acrylamide neuropathy: an electrophysiological approach"],"prefix":"10.1111","volume":"22","author":[{"given":"H.","family":"Perez\u2010Saad","sequence":"first","affiliation":[{"name":"Department of Pharmaceuticals, Division of Biomedical Research Center for Genetic Bioengineering and Biotechnology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Subiros","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, Division of Biomedical Research Center for Genetic Bioengineering and Biotechnology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Berlanga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, Division of Biomedical Research Center for Genetic Bioengineering and Biotechnology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Aldana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, Division of Biomedical Research Center for Genetic Bioengineering and Biotechnology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3654-490X","authenticated-orcid":false,"given":"D.","family":"Garcia del Barco","sequence":"additional","affiliation":[{"name":"Department of Pharmaceuticals, Division of Biomedical Research Center for Genetic Bioengineering and Biotechnology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1097","article-title":"Protective effect of a mixture of gangliosides in acrylamide neuropathy in mice","volume":"30","author":"Acevedo ME","year":"2000","journal-title":"Rev Neurol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310390231"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn295"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00023.x"},{"key":"e_1_2_6_6_1","first-page":"117","article-title":"Stevenel's Blue, an excellent stain for optical microscopical study of plastic embedded tissues","volume":"8","author":"Del Cerro M","year":"1980","journal-title":"Microsc Acta"},{"key":"e_1_2_6_7_1","first-page":"100","article-title":"Growth factors in wound healing. 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