{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:54:45Z","timestamp":1789880085389,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Capital Health Research and Development of Special Fund","award":["2014-2-5012"],"award-info":[{"award-number":["2014-2-5012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mercury and its compounds possess strong neurotoxicity and patients with mercury poisoning often report pain and numbness in the distal extremities that conform to the \u201cstocking\u2013glove\u201d pattern. However, no study has investigated whether damage to small nerve fibers is associated with mercury poisoning. The aims of the present study were to evaluate the effects of different doses of mercury chloride (HgCl<jats:sub>2<\/jats:sub>) on intraepidermal nerve fibers density (IENFD) and Langerhans cells (LCs) in the plantar skin of rats and to assess the possible relationship between changes in IENFD and sensory testing. Male Sprague\u2013Dawley rats were divided into three experimental groups and administered HgCl<jats:sub>2<\/jats:sub> solutions <jats:italic>via<\/jats:italic> gavage at three different doses (4.25, 8.5, and 17\u2009mg\/kg\/day) for 21\u2009days. Subsequently, behavioral tests and pathological changes in IENFD and LCs were assessed at three different time points (1, 2, and 3\u00a0weeks). Rats in all three HgCl<jats:sub>2<\/jats:sub> groups exhibited varying degrees of weight and hair loss. Thermal hypersensitivity was evident in all the HgCl<jats:sub>2<\/jats:sub> groups (for middle\u20102w subgroup, p\u00a0&lt;\u00a00.05). Mechanical sensitivity tests revealed hyposensitivity in all the HgCl<jats:sub>2<\/jats:sub> groups except the high\u20101w subgroup. Significant decreases in IENFD (for the high\u20101w, middle\u20101w, low\u20102w, and low\u20103w subgroups, p\u2009&lt;\u20090.05) and significant increases in the density of LCs (except for the low\u20101w and high\u20102w subgroups, all p\u00a0&lt;\u00a00.05) were found in all groups after HgCl<jats:sub>2<\/jats:sub> exposure. An association analysis revealed a significant correlation between the decrease in IENFD and the increase in LCs densities (r\u2009=\u2009\u22120.573, p\u2009&lt;\u20090.01). The present study demonstrated a decrease in IENFD and an increase in LCs density in the plantar skin of rats after HgCl<jats:sub>2<\/jats:sub> poisoning, indicating that damage of the small nerve fibers occurs after mercury poisoning.<\/jats:p>","DOI":"10.1111\/jns.12246","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T05:42:46Z","timestamp":1511415766000},"page":"17-22","source":"Crossref","is-referenced-by-count":6,"title":["Changes in intraepidermal nerve fiber and Langerhans cell densities in the plantar skin of rats after mercuric chloride exposure"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-423X","authenticated-orcid":false,"given":"Binbin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology Chinese PLA General Hospital  Beijing P.R. China"},{"name":"Department of Neurology 307 Hospital, Chinese PLA  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology 307 Hospital, Chinese PLA  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology 307 Hospital, Chinese PLA  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chinese PLA General Hospital  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Chinese PLA General Hospital  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"11","article-title":"Assessment of acute thermal nociception in laboratory animals","volume":"99","author":"Allen JW","year":"2004","journal-title":"Methods Mol Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/460508"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1100-3"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Mercury toxicity and neurodegenerative effects","volume":"229","author":"Carocci A","year":"2014","journal-title":"Rev Environ Contam Toxicol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb07331.x"},{"key":"e_1_2_7_8_1","first-page":"111","article-title":"Human health effects of methylmercury exposure","volume":"198","author":"Diez S","year":"2009","journal-title":"Rev Environ Contam Toxicol"},{"key":"e_1_2_7_9_1","first-page":"745","article-title":"Inductively coupled plasma mass spectrometry for the simultaneous determination of thirty metals and metalloids elements in blood samples","volume":"46","author":"Ding CG","year":"2012","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.036"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/815186"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0181-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00269.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32835804c5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.3.333"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2014.10.008"},{"key":"e_1_2_7_17_1","first-page":"1","article-title":"Toxicology and carcinogenesis studies of mercuric chloride (CAS no. 7487\u201094\u20107) in F344 rats and B6C3F1 mice (gavage studies)","volume":"408","author":"National Toxicology Program","year":"1993","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.03.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.2012.45.6.344"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2012.02.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.12.1369"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(74)90113-8"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:28:43Z","timestamp":1695572923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/jns.12246"],"URL":"https:\/\/doi.org\/10.1111\/jns.12246","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]}}}